Goljan audio mistake (about liver) ?????? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 02-20-2014
USMLE Forums Scout
Steps History: Not yet
Posts: 31
Threads: 16
Thanked 3 Times in 3 Posts
Reputation: 13
Default Goljan audio mistake (about liver) ??????

Hi guys I am going to post some notes written about Goljan audio, I would like you to correct me if I am wrong but I believe a mistake was made. Here is what is written

Blockage of hepatic vein leads to budd chiari and liver becomes congested. Which part of liver is most susceptible to injury normally? Around central vein, b/c it gets first dibbies on O2 coming out of the sinusoids (zone 1). Zone 2 is where yellow fever will hit (midzone necrosis) due to ides egypti. Zone 3, around portal vein, which will have least O2 (analogous to renal medulla, which only receives 10% of the blood supply, and the cortex receives 90%). Fatty change is around zone 3 (part around central vein). Therefore, when asking about acetaminophen toxicity, which part is most susceptible? Around the central vein b/c it gets the least amount O2, and therefore cannot combat free radical injury.

In my belief

Zone 1= area closest to the portal triad ( hepatic artery , portal vine, bile/hepatic duct).

zone 2= area in between the portal triad (area) and the central vein(area).

zone 3 = area immediately surrounding central vein. = "last dibbies on oxygen not first"

Also I believe that :

zone 1= most oxygen, least susceptible to oxygen deprivation injury).

zone 3= least oxygen most suceptible to oxygen deprivation necrosis a la coagulation necrosis (possible causing a hemorrhagic infarct)?

zone 2= yellow fever--> in mid zone necrosis in the area in between triad and central vein?

If I am worng please correct me !

PS,I have a question someone please describe fatty change in liver due to oxygen deprivation or free radical injury.

thanks in advance !!!!!
Reply With Quote Quick reply to this message


Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
for those looking for Goljan Audio AMOONA USMLE Step 1 Forum 219 02-27-2017 07:19 PM
is goljan audio enough ? please i need help Amr Tarek Saleh USMLE Step 1 Forum 1 01-07-2014 12:01 PM
Goljan Audio ele0812 USMLE Step 1 Forum 0 01-02-2014 05:57 PM
Goljan Audio please..... Master shifu USMLE Step 1 Forum 3 08-20-2013 02:43 AM
Need Goljan Audio mbekhit12 For Sale & Wanted Items 1 04-07-2012 08:59 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)