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Old 10-13-2009
YoramFishke's Avatar
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DNA Tumor Suppressor Genes

OK, I have a question

Is HPV or Adenovirus associated with E6,E7 mutations that cause tumor suppressor deletions p53 and rb?

Am quite confused about this

Thanks for the help
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Old 10-13-2009
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HPV gene products are called E6 and E7 and they inhibit P53 and Rb tumor suppressor genes respectively.

Adenovius produce E1A and E1B and they inhibit Rb and P53 tumor suppressor genes respectively. However, Adenovirus tumorgenic capabilities have been only demonstrated in vitro and no documented cases of human cancers.
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