Which drug has predictable bioavailibilty? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 01-06-2011
kemoo's Avatar
USMLE Forums Guru
 
Steps History: 1+CK+CS
Posts: 378
Threads: 161
Thanked 102 Times in 51 Posts
Reputation: 116
Drug Which drug has predictable bioavailibilty?

NBME FORM 1

which of the following antimicrobial agents most likely to be administered orally for the treatment of potentially serious systemic infections because of its
predictable bio-availability ??

A) Amphotricin B

B) Ciprofloxacin

C) Gentamicin

D) polymexin B

E) Vancomycin
Reply With Quote Quick reply to this message
The above post was thanked by:
dr pinky (01-16-2011)



  #2  
Old 01-06-2011
dr z's Avatar
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 136
Threads: 34
Thanked 349 Times in 89 Posts
Reputation: 369
Warning! B

i think B: ciprofloxacin
Reply With Quote Quick reply to this message
The above post was thanked by:
dr pinky (01-16-2011)
  #3  
Old 01-06-2011
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Arrow

Answer is B) Ciprofloxacin

Because, out of all choices ciprofloxacin has the highest bioavailability if administrated orally.
Reply With Quote Quick reply to this message
The above post was thanked by:
Dulbee (01-06-2011)
  #4  
Old 01-07-2011
kemoo's Avatar
USMLE Forums Guru
 
Steps History: 1+CK+CS
Posts: 378
Threads: 161
Thanked 102 Times in 51 Posts
Reputation: 116
Default

Quote:
Originally Posted by aktorque View Post
Answer is B) Ciprofloxacin

Because, out of all choices ciprofloxacin has the highest bioavailability if administrated orally.

thanks but why other medication have low oral bioavailability?

if u have good explanation for this question

thank u
Reply With Quote Quick reply to this message
  #5  
Old 01-07-2011
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Arrow

Vancomycin - it has to be given intravenously (IV) for systemic therapy since it does not cross through the intestinal lining. It is a large hydrophilic molecule which partitions poorly across the gastrointestinal mucosa. The only indication for oral vancomycin therapy is in the treatment of pseudomembranous colitis, where it must be given orally to reach the site of infection in the colon.

Amphotricin B - A major barrier to the use of amphotericin in resource-poor settings is that it must be given intravenously (except for topical applications). An oral preparation exists, but is not yet commercially available.

Gentamycin - since their large polarized molecular size, they are not absorbed from the gut, they are administered intravenously and intramuscularly. Some are used in topical preparations for wounds. Oral administration can be used for gut decontamination (e.g., in hepatic encephalopathy)

hope this help you....
Reply With Quote Quick reply to this message
The above post was thanked by:
dr pinky (01-16-2011), drHubaishi (09-11-2014), Hitman (12-04-2011), kemoo (01-07-2011)



Reply

Tags
Pharmacology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
How Predictable and Difficult is NBME Form 4? dr.valium USMLE Step 1 Forum 2 11-01-2010 03:22 PM
question - lithium toxicity drug-drug interaction mtoi USMLE Step 1 Forum 5 10-31-2010 01:48 PM
Drug resistance? dheshah USMLE Step 1 Forum 1 09-07-2010 11:37 AM
Drug of choice for this? sam01 USMLE Step 1 Forum 10 08-17-2010 03:53 AM
Which drug is useful for this patient? RRMadukha USMLE Step 2 CK Forum 4 06-28-2010 07:16 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)