NBME form 7 - Hypoglycemia - Enzyme Deficiency! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 01-07-2011
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Biochemistry NBME form 7 - Hypoglycemia - Enzyme Deficiency!

A 9 month old girl is brought to ER 30 mins after she had generalized tonic-clonic seizures. She has had failure to thrive & developmental delay since birth. She is at the 3rd percentile for length & weight. Physical exam shows microcephaly, tachypnea, & hypotonia. Lab studies show hypoglycemia, hyperalaninemia, & lactic acidosis. After I/V glucose is administered, her serum glucose concentration returns to within the reference range. This patient most likely has a deficiency of which of the following enzyme activities?

a) glucokinase
b) glyceraldehydes-3-phosphate dehydrogenase
c) hexokinase
d) pyruvate carboxylase
e) triose-phosphate isomerase

Please try....
Reply With Quote Quick reply to this message



  #2  
Old 01-07-2011
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Arrow

What do you guys think... should it be D)
Reply With Quote Quick reply to this message
  #3  
Old 01-07-2011
USMLE Forums Veteran
 
Steps History: 1+CK+CS+3
Posts: 281
Threads: 11
Thanked 196 Times in 132 Posts
Reputation: 206
Default

Im thinking D also, liver starts 2 break down glycogen, which since it cant do this...the body must use lactic acid as an energy source... makes sense... final answer.. D
Reply With Quote Quick reply to this message
The above post was thanked by:
aktorque (01-07-2011)
 
  #4  
Old 01-08-2011
USMLE Forums Scout
 
Steps History: Not yet
Posts: 45
Threads: 0
Thanked 31 Times in 21 Posts
Reputation: 41
Default

sounds like a defect in gluconeogenesis because baby having-
Hypoglycemia + hyperalaninemia the baby most probably has pyruvate carboxylase deficiency
Reply With Quote Quick reply to this message
The above post was thanked by:
aktorque (01-08-2011), Amenah (01-08-2011)
  #5  
Old 03-06-2011
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 6
Threads: 1
Thanked 6 Times in 2 Posts
Reputation: 16
Default

Quote:
Originally Posted by JJtheMD View Post
Im thinking D also, liver starts 2 break down glycogen, which since it cant do this...the body must use lactic acid as an energy source... makes sense... final answer.. D
Definitely is D we don't have oxaloacetate but increase the alanine.
Reply With Quote Quick reply to this message



Reply

Tags
Biochemistry-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
B12 deficiency getting worse with folate deficiency Androide89 USMLE Step 1 Forum 10 06-20-2016 04:19 AM
Infant's Enzyme Deficiency FreakingOut USMLE Step 1 Forum 4 05-17-2010 02:42 PM
Which enzyme deficiency causing this hemolytic anemia? sam01 USMLE Step 1 Forum 8 04-14-2010 05:17 AM
Hepatic enzyme deficiency! Farazdaq USMLE Step 1 Forum 0 02-10-2010 07:09 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)