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Old 01-12-2011
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Neuro Leptin receptors in the hypothalamus

where r they situated in the brain ? which nuclei of hypothalamus ?
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Old 01-12-2011
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Default Is it known yet?

I don't think it's yet known where the leptin receptors are situated in the hypothalamus.

If I were to improvise, I'd pick the ventromedial nucleus as it's responsible for satiety , see this Hypothalamic Nuclei
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Old 01-12-2011
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that was the first thing that i thought , but wikipedia says possibly near the arcuate nucleus?
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also high yield histology writes while discussing leptin in chapter of connective tissue that paraventricular and arcuate nucleus are the site.
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Old 01-12-2011
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Abbreviations: AgRP, Agouti-related peptide; BDNF, brain-derived neurotrophic factor; CART, cocaine and amphetamine related transcript; MC3R, melanocortin 3 receptor; MC4R, melanocortin 4 receptor; NPY, neuropeptide Y; POMC, pro-opiomelanocortin gene; TrkB, tyrosine kinase receptor B; Y1R, neuropeptide Y receptor Y1.

Leptin-induced signaling in the Arcuate nucleus of the hypothalamus. Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity.
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Old 01-14-2011
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thanx for the detailed reply
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