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Old 03-10-2014
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Default signal tranduction pathways???

I wonder how extensively should we konw signal transduction pathways????

First aid 2014 level is fine?
Should we memorize the whole pathways???
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Old 03-10-2014
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What pathways are you talking about in general?
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Old 03-10-2014
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Insulin-> Tyrosine kinase -> IP3 pathway, MAP kinase
Cytokine receptor -> JAK-STAT pathway
TGF-β

etc......
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Old 03-11-2014
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Quote:
Originally Posted by med89 View Post
Insulin-> Tyrosine kinase -> IP3 pathway, MAP kinase
Cytokine receptor -> JAK-STAT pathway
TGF-β

etc......
You definitely want to know all the major pathways. On my Step, there were questions that involved receptors/proteins/pathways that I hadn't heard of before. However, there were clues that indicated it functioned in a way similar to one of the common pathways, albeit with different names. The question will then require you to infer what will happen next based on what would happen in the canonical pathways.
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Old 04-08-2015
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Can anyone suggest me a good source to read signal transduction? I just read the chart that is given in FA but I think its not enough as they are asking more in questions like uworld.
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Old 04-08-2015
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Smile YES!

This is probably not what you wanted to hear, but all of the signal transduction are heavily tested. They make multiple appearances in USMLE World with good reason, and I know they appeared on my step 1. Importantly also, you need to know which hormones/signals use which receptors (there is a graph in the First Aid in the endocrine section (at least in the 2015 edition, can't speak for other editions) which you must memorize- so you're on the right track on that front!!)

And there's a good point brought up- for some weird reason, First Aid doesn't give the pathways their due importance! But I went ahead with the advice that people on these forums gave and studied the hell out of them :P and I'm glad I did.

As for where I learned them- what I found best was to correlate the USMLE World answer interpretation with video animations I found on youtube, which helped *immensely*. I also struggled with these receptors, but I found USMLE world gave the best and most basic explanations (well, at least told you the bare minimum of what you needed to know.)

Hope that helped, and best of luck!
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sayeda humaira (04-08-2015)



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