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  #1  
Old 10-18-2009
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Question Lymphadenopathy Hepatomegaly

12 year old with lymphadenopathy hepatomegaly lymphocytosis autoimmune features and persistent lymphocytes activation after exposing his blood sample to T cell mitogen.

What is your diagnosis?
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  #2  
Old 10-18-2009
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Ok it seems that nobody can answer your question

Why don't you tell us the correct answer?
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  #3  
Old 10-18-2009
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Canale Smith Syndrome
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Old 10-19-2009
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Quote:
Originally Posted by Padrig View Post
Canale Smith Syndrome

i thought in this syndrome .. but there is no lymphocytosis in it .. as i remember ...

it ofcource it goes with FAS mutation
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Old 10-19-2009
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Quote:
Originally Posted by Betro Sadek View Post
i thought in this syndrome .. but there is no lymphocytosis in it .. as i remember ...

it ofcource it goes with FAS mutation
They don't give you everything in USMLE, the fact there's lymphoid organs enlargement is enough to point to an activated immune system.

Yes, of course it's Fas and FasL mutation so that they don't work so that activated T lymphocytes don't kill each other after finishing their job.
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Old 09-04-2010
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Default Canale Smith Syndrome

can some explain clearly about Canale Smith Syndrome? plz
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Old 09-04-2010
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Quote:
Originally Posted by karthiksamineni View Post
can some explain clearly about Canale Smith Syndrome? plz
All you need to know for the USMLE is this;
Canale smith syndrome = activated lymphocytes due to FAS gene mutation, this activation leads to lymphadenopathy and autoimmunity.
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Immunology-, Step-1-Questions, Syndromes-Acronyms

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