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  #1  
Old 01-21-2011
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Bacteria TH1 Response and bacterial infection

I am reading a question from FA and I quote "TH1 lymphocytes, not TH2, are predominantly stimulated by bacteria and viruses..."

!!!!!!???? Is that true? Until now I thought that TH2 cells are for bacteria and TH1 cells are for viruses.

Isn't TH2 cells provide stimulation for B cells to activate them during humeral immune response?

Please let me know what I am missing here :sorry:
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  #2  
Old 01-21-2011
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Quote:
Originally Posted by hana View Post
I am reading a question from FA and I quote "TH1 lymphocytes, not TH2, are predominantly stimulated by bacteria and viruses..."

!!!!!!???? Is that true? Until now I thought that TH2 cells are for bacteria and TH1 cells are for viruses.

Isn't TH2 cells provide stimulation for B cells to activate them during humeral immune response?

Please let me know what I am missing here :sorry:

Th1 is to remove intracellular pathogens.
Th2 to remove extracellular pathogens.
Remember viruses are removed by cytotoxic CD8 cells.
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Old 01-21-2011
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Quote:
Originally Posted by evavar View Post
Th1 is to remove intracellular pathogens.
Th2 to remove extracellular pathogens.
Remember viruses are removed by cytotoxic CD8 cells.
then again same q;why FA says TH1 are predominatly stimulated by bacteria? i understand the virus part.
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Old 01-21-2011
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Quote:
Originally Posted by hana View Post
then again same q;why FA says TH1 are predominatly stimulated by bacteria? i understand the virus part.

Yes, intracellular bacteria. Check out in the first pages of microbiology in FA the intracelullar bacteria. There you have a couple, those bacteria are the ones that stimulate TH1.
The TH2 is a response to extracellular bacteria, where you need antibodies.
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Old 01-22-2011
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Quote:
Originally Posted by evavar View Post
Yes, intracellular bacteria. Check out in the first pages of microbiology in FA the intracelullar bacteria. There you have a couple, those bacteria are the ones that stimulate TH1.
The TH2 is a response to extracellular bacteria, where you need antibodies.
agree.but still we can not say TH1 ARE PREDOMINANTLY STIMULATED BY BACTERIA. b/c most bacteria are NOT INTRACELLULAR. do not you think so?
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Old 01-25-2011
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Question

-one theory suggests that vaccine administration may alter Th COMPOSITION AND/OR IMMUNOGLOBLINE level.which of the following statments depicts the theoretical affects of vaccines on immune system that may lead tp allregies/autoimmune diseae?

1-decreased Th1 leads to increased Th2
2-decreased Th2 leads to increased Th1
3-increased Th1 leads to increas in TH2
4-inceased in TH1 leads to increase in IgE
5-INCREASED tH2 LEADS TO INCREASED IgE
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Old 01-25-2011
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Type 1 helper (TH1) T cell immune responses are critical for the control of viruses and intracellular bacteria. Immunologists have generally believed that TH1 responses are induced by rare immune cells, called dendritic cells. When activated by infection or vaccination, the dendritic cells were thought to move from peripheral tissues into lymph nodes to stimulate T cell responses.

The dendritic cells that stimulate TH1 responses didn't come from peripheral tissues, but rather arose from monocytes, a common cell type in the blood, that moved directly into lymph nodes after infection. This finding will have important implications in vaccine science and autoimmune disease therapy development.

I have a diagram that shows this mechanism very brief. (Just look at the diagram a)
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  #8  
Old 01-25-2011
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its obvious bacteria gives a TH2 response....
but virus can also give a Th2 response as u mite be knowing some viral proteins are expressed on cell surface of the target cell causing antibody formation leading to ADCC by NK cells
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Old 01-26-2011
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i JUST remembered from UW,that during vaccination humeral system becomes involved ,not cellura.reason is that we are either giving paitient weak or dead patogen which are not able to go INTO cell and there is no use for th1 here,or we r giving Ig which again has nothing to do with th1.
based on this i expect more th2 activation so th2/th1 ratio increase and this is the reason of more allergi reactions.
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  #10  
Old 06-20-2011
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Post Notes about Vaccination

Quote:
Originally Posted by hana View Post
i JUST remembered from UW,that during vaccination humeral system becomes involved ,not cellura.reason is that we are either giving paitient weak or dead patogen which are not able to go INTO cell and there is no use for th1 here,or we r giving Ig which again has nothing to do with th1.
based on this i expect more th2 activation so th2/th1 ratio increase and this is the reason of more allergi reactions.
Some points about vaccines:

1- Vaccine for Haemophilus influenza type B is a T-cell dependent vaccine.

2- Living viral vaccines elicit both Cell-mediated immunity (CMI) and humoral-mediated immunity (HMI).

3- Killed viral vaccines elicit antibodies.
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