Inhaled Anesthetics - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 01-21-2011
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 2
Threads: 1
Thanked 0 Times in 0 Posts
Reputation: 10
Anesthesiology Inhaled Anesthetics

i need help with inhaled anesthetic topics, blood/gas partition coefficient. I don't understand why more soluble anesthetic has slow onset of action. i am really confused.
Reply With Quote Quick reply to this message



  #2  
Old 01-21-2011
dr z's Avatar
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 136
Threads: 34
Thanked 349 Times in 89 Posts
Reputation: 369
Idea! More soluble , easy diffusion cross lipid memb

the more soluble the gas the more it diffuses back and forth in blood and lipid tissues CNS so it takes longer to achieve INDUCTION (high potency)

drugs with increase solubility in lipids = increase potency = inverse MAC like HALOTHANE
Reply With Quote Quick reply to this message
The above post was thanked by:
dr pinky (01-24-2011)
  #3  
Old 01-22-2011
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 2
Threads: 1
Thanked 0 Times in 0 Posts
Reputation: 10
Default

but why has low onset of action? it has not logic for me.
this is the only topic that make me crazyyyyyyy
Reply With Quote Quick reply to this message
 
  #4  
Old 01-22-2011
dr z's Avatar
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 136
Threads: 34
Thanked 349 Times in 89 Posts
Reputation: 369
Default redistribution of lipid soluble drugs

to achieve a therapeutic effect u have to get a suitable amount/concentration of drug in blood or the targeted tissue ( CNS here)

so whan the drug is so diffusable then it would require a very high plasma concn to achieve an effective CNS conc and haothane family ossilates between the two compartment so it is hard to achieve onset of action fast.
hope this helps
Reply With Quote Quick reply to this message
The above post was thanked by:
dr pinky (01-24-2011), Y.MD (01-22-2011)



Reply

Tags
Pharmacology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Inhaled Anaesthetics Blood Lipid Coefficient DrSeddik USMLE Step 1 Forum 2 03-20-2012 07:54 PM
Mechanism of Local Anesthetics Dr.MonMon USMLE Step 1 Forum 1 05-12-2010 02:58 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)