HIV cannot be defeated by allelic exclusions - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 01-22-2011
adorisz's Avatar
USMLE Forums Scout
Steps History: 1 + CK
Posts: 54
Threads: 15
Thanked 46 Times in 21 Posts
Reputation: 56
Virus HIV cannot be defeated by allelic exclusions

I read that HIV bypasses allelic exclusion because it carries 2 copies of ssDNA. I cant really understand how that works. Can somebody please explain?????

Thanks in advance for ur help!
Reply With Quote Quick reply to this message

Old 01-22-2011
USMLE Forums Scout
Steps History: Not yet
Posts: 55
Threads: 4
Thanked 107 Times in 28 Posts
Reputation: 117

HIV is a double stranded virus, means it has two strands to integrate into the host chromosome.

Lets say it infects a developing T/B cell, one of the chromosomes in the cell gets excluded because it produces a faulty TCR/IG epitope that binds it too tightly to self antigens, this would effectively kill the integrated provirus in the excluded chromosome.

But, HIV has got ways to get around this, the second copy integrates into the homolog (we all have homologs remember?) , so HIV cant be defeated by allelic exclusion.
Reply With Quote Quick reply to this message
The above post was thanked by:
adorisz (01-22-2011), dr z (01-22-2011), kundra (01-22-2011), Mondoshawan (01-22-2011), Sabio (01-22-2011)



Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
most common cause of meningitis in HIV pt?? zinah USMLE Step 2 CK Forum 7 06-20-2010 10:12 AM
HIV resistant strains achistikbenny USMLE Step 1 Forum 2 06-09-2010 11:45 AM
HIV patient who needs meds inder USMLE Step 1 Forum 6 06-07-2010 08:19 AM
HIV Diagnosis Question lemontea88 USMLE Step 1 Forum 4 12-04-2009 04:37 PM
HIV Replication and pharmacology options Betro Sadek USMLE Step 1 Forum 4 10-19-2009 02:23 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)