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Old 01-24-2011
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Question Why Polycythemia in Carcinoma

Hi can someone explain why we have polycythemia in Hepato Cellular Carcinoma and Renal Cell Carcinoma ?

Thanks :-)
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Old 01-24-2011
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Default inappropiate polycythemia

polycythemia is the one occuring in carcinomas , like RCC HCC
inappropriate absolute polycythemia.
labs
plasma vol increase
RBC mass increase
Erythropoietn increase
oxygen sat no effect.
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Old 01-24-2011
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I guess its the para-neoplastic syndrome of HCC and RCC, both tumors can secrete Erythropoietin and therefore polycythemia - an eg for secondary polycythemia, ectopic EPO secretion
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Old 01-24-2011
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are you sure?
because i have read Polycythemia vera is the clonal expansion of myeloid stem cells due to JAK 2 mutations on chromosome -9 with increased counts across all cell lines meaning, erythrocytes, platelets, granulocytes. EPO is characteristically low in Polycythemia vera

where as HCC and RCC are ectopic EPO producers leading to high serum EPO levels therefore causing only erythrocytosis and absolute polycythemia
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Old 01-24-2011
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Default erythropoeitin is the cause

It is polycythemia NOT polycythemia vera in these malignancies..and it is because of increased erythropoietin
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Old 01-24-2011
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Unhappy my mistake!

Yes u r right, i made a mistake, as this was written in FA chart of POLYCYTHEMIA
now i checked from goljan and i m correcting it

Inappropriate absolute polycythemia: ectopic EPO production
No hypoxic stimilus for EPO release
etopic release of EPO from renal cell carcinoma
Increased RBC count. RBC mass. EPO
Normal PV and SaO2
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