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  #1  
Old 01-24-2011
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Immunology Graft Versus Host Disease

Hi everyone...

Please someone help me with this....

In which disease GVHD does not occur and why??

I know one...it does not occur if recipient has AIDS due to destruction of T cells by HIV virus
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Old 01-25-2011
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Arrow Clearing concepts

GVHD does occur in HIV patients, who said it's not!

For GVHD to occur you need the following:
- Immunocompetent graft given to the recipient (the graft has functioning T cells)
- Immunocompramised recipient (cannot destroy the grafted T cells)

Therefore, GVHD occur only when you transplant a bone marrow or give blood transfusion (as these are the only organs that can have function T cells).

It cannot happen with any other organ transplantation such liver, kidney, heart, ...etc

Please let me know if you still need further explanation.
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  #3  
Old 01-25-2011
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it is mentioned in kaplan immunology lecture videos along with sum other disease like SCID, digeorge syndrome....

i ran google search for them but could only understand the case of AIDS...google returns with alot of pages if searched for "gvhd in aids".

check dis link
http://journals.lww.com/jaids/Abstra...Disease.6.aspx
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Old 01-25-2011
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Arrow Let may repeat myself

You either misunderstood Kaplan or they are wrong.

There's nothing like no GVHD in AIDS patients. This is statement is WRONG.

Perhaps, they were saying if the donor graft is coming from an HIV patient, then it won't affect the recipient. But such a scenario is not at all applicable in real life, because nobody will allow an HIV infected bone marrow to be donated

My friend, GVHD happens when the transplanted bone marrow (that has T cells) attacks the recipient tissues (that are immunocompramised). So an AIDS, SCID, or Digeogre patients are perfect victims of GVHD.
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Old 01-25-2011
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Quote:
Originally Posted by Hokolesqua View Post
You either misunderstood Kaplan or they are wrong.

There's nothing like no GVHD in AIDS patients. This is statement is WRONG.

Perhaps, they were saying if the donor graft is coming from an HIV patient, then it won't affect the recipient. But such a scenario is not at all applicable in real life, because nobody will allow an HIV infected bone marrow to be donated

My friend, GVHD happens when the transplanted bone marrow (that has T cells) attacks the recipient tissues (that are immunocompramised). So an AIDS, SCID, or Digeogre patients are perfect victims of GVHD.

Im not sure about the HIV thing but it does sound about right to me aie if there are no tcells ( in the graft) how can they attack the host

BUT u are wrong about the GVHD only occuring in BM and blood transfusion from what i remembered its possible in any solid organ transplant i specifically remembered it in the liver so i searched to make sure i wasnt rememembering wrong ( a very comman occurance) and found this

"
  • GVHD may be associated with different types of transplants.
  • GVHD has been reported after solid organ transplantation (especially that involving the liver) and after the transfer of immunocompetent maternal cells to a relatively immunosuppressed fetal recipient"
HEres the full article just for referance http://emedicine.medscape.com/article/1050580-overview
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Old 01-25-2011
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thanks hokolesqua...

the lady was not clear about dis in lecture..so i mite hav misunderstood it..
sry for the trouble

wat do u think if the DONOR has SCID or degeorge syndrome..wil there be any GVHD???
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Old 01-25-2011
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Guys... its Bare Lymphocyte Syndrome which is mentioned in the notes (so prob. in videos) that in which NO GVHD would occur
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Old 01-25-2011
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Quote:
Originally Posted by docnas View Post
if there are no tcells ( in the graft) how can they attack the host
I did mention that if the donor is immunocompramised then there will be no GVHD. But who will give an HIV infected bone marrow
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Old 01-25-2011
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Quote:
Originally Posted by docnas View Post
GVHD has been reported after solid organ transplantation (especially that involving the liver) and after the transfer of immunocompetent maternal cells to a relatively immunosuppressed fetal recipient"
Whenever they say (has been reported) means that's not a common occurring. When we talk GVHD we usually talk BMT.
But you are right it can be seen after solid organ transplant specially the liver, because the liver is part of the lymphoreticular system and it may contain active T cells.
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Old 01-25-2011
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i checked the video again she mentions these 4 disease
1 scid
2 bare lymphocyte syndrome
3 digeorge
4 aids(though not given as hokolesqua said)

if any of the disease is present in the DONOR(not recipient) there wil be no gvdh because they all will be deficient in t cells...
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Old 01-25-2011
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Default that makes sense

Quote:
Originally Posted by rsin21 View Post
i checked the video again she mentions these 4 disease
1 scid
2 bare lymphocyte syndrome
3 digeorge
4 aids(though not given as hokolesqua said)

if any of the disease is present in the DONOR(not recipient) there wil be no gvdh because they all will be deficient in t cells...
So that makes sense. If these disease present in the donor bone marrow not the recipient. But I still don't understand how come an AIDS patient (or even the other immunocompramised patients you listed) go give their bone marrow, unless it's a hidden disease maybe.
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Old 01-25-2011
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I think she said AIDS just for listing disease with deficient T cells...though it wont be used for BMT

Thanks every1
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Old 02-07-2012
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1. Graft vs host disease does not develop in MHCII defeciency because the host lacks the the MHCII molecules against which the donor T cells can react,

2.Transfusion of immunocompetent cells into HIV-1-infected subjects results in an in vivo allogeneic cell response. The activated CD4+ T cells become infected with HIV-1 and are rendered immunologically incompetent or are destroyed and cannot, therefore, initiate GVHD, (its just a hypothesis)

3.digeorge syndrome and SCID , no idea about them, any way i think of it cant figure out why GVHD wouldnt develop!!
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