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Old 01-28-2011
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DNA Topoisomerase I relax supercoils?

Does topoisomerase I relax supercoils?
Does that mean it causes negative supercoiling of DNA?
and how does that occur?
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Old 01-29-2011
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Hey.
Yes, Toposismorase I relaxes super-coils. It does so by cutting 1 DNA strand.
Topoismorease II also relaxes super-coils but does so by cutting both DNA strands.
When you relax (decrease) a coil it is called Negative super-coiling. (removing stress)
When you increase the coil it is called positive super-coiling.
Tpoisomerase works by cutting the strand, passing it through the other strand and annealing it back.

Hope this is helpful.
Good luck!
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Old 01-30-2011
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Quote:
Originally Posted by Myticketout View Post
Hey.
Yes, Toposismorase I relaxes super-coils. It does so by cutting 1 DNA strand.
Topoismorease II also relaxes super-coils but does so by cutting both DNA strands.
When you relax (decrease) a coil it is called Negative super-coiling. (removing stress)
When you increase the coil it is called positive super-coiling.
Tpoisomerase works by cutting the strand, passing it through the other strand and annealing it back.

Hope this is helpful.
Good luck!
Thanks Alot. I thas been very helpful.
Best of luck to you too.
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Old 01-30-2011
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Quote:
Originally Posted by Myticketout View Post
Hey.
Yes, Toposismorase I relaxes super-coils. It does so by cutting 1 DNA strand.
Topoismorease II also relaxes super-coils but does so by cutting both DNA strands.
When you relax (decrease) a coil it is called Negative super-coiling. (removing stress)
When you increase the coil it is called positive super-coiling.
Tpoisomerase works by cutting the strand, passing it through the other strand and annealing it back.

Hope this is helpful.
Good luck!

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The above post was thanked by:
hope007 (01-30-2011), Sabio (01-30-2011)



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