Normal and Myeloma Urinary Immunoglobulin Light Chain! - USMLE Forums
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Old 02-05-2011
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Urine Sample Normal and Myeloma Urinary Immunoglobulin Light Chain!

Dear all the member,

Which type of Ig light chain is common in urine of Myeloma patient ?
Which type is common in normal person ?



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Old 02-05-2011
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Free Light Chains are normally seen in urine.
In multiple myeloma you have Bence Jones Proteins
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Old 02-05-2011
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Default Normal and Myeloma Urinary Immunoglobulin Light Chain

Quote:
Originally Posted by 13monument View Post
Free Light Chains are normally seen in urine.
In multiple myeloma you have Bence Jones Proteins

Thanks. But what type of light chain, kappa or lambda ?
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Old 02-05-2011
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Info It's the ratio, not the type, that's diagnostic

Normally, a small amount of free light chains are everywhere - about a 2:3 ratio of free kappa chains to lambda chains. If you were doing an immunoassay, it would count whole antibodies as well as free chains, and the ratio would be more like 2:1.

In myeloma, the production is monoclonal, so you will see a profile that deviates from this norm. It doesn't matter how much protein you have - indeed, if the kidneys haven't been damaged enough yet, the urine protein level could be normal - but the ratio will be altered because so much of one kind of light chain is being produced. Once there is sufficient glomerular damage, the Bence Jones proteins (crystallized agglomerations of light chain) will appear in the urine, as well as casts. Kappa is the most common, according to Goljan (p. 247 RR Pathology 3e).
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02tones02 (07-03-2013), 13monument (02-05-2011), adrenaline rush (02-05-2011), aktorque (02-06-2011), Cairo (02-06-2011), chulady (02-05-2011), dr_ram (02-06-2011), Sana Zahid (02-11-2011)



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