Alpha 1 Antitrypsin Secretion in the lung! - USMLE Forums
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Old 02-08-2011
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Lungs Alpha 1 Antitrypsin Secretion in the lung!

i have a question
in a normal lung , what secrets alpha 1 anti trypsin that protects the lung from Emphysema??
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Old 02-08-2011
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I think that, although it acts in the lung, it is actually made and secreted by the liver.
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Old 02-08-2011
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Default Alpha-1 antitrypsin

I think,as it is a protease inhibitor, it should be synthesized in all cells to protect from the effect of inflammatory cells during inflammation.
But its deficiency is most obvious in the lung and liver because they are subjected to frequent infections especially the lung and toxic metabolite in case of the liver.
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Old 02-08-2011
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but guys the cells that secret it ,what s its name??
is it type 2 pulmonary cells??
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Old 02-08-2011
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Quote:
Originally Posted by geof1 View Post
but guys the cells that secret it ,what s its name??
is it type 2 pulmonary cells??
No!! type 2 pneumocytes secrete ' surfactant' which opposes surface tension force ..surfactant expand the lungs by opposing surface tention..
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Old 02-09-2011
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LIVER CELLS synthesize and secrete it and it works in the lung , it's defeciency is caused by defective protien transporter into the blood stream , so it will accumulate in the liver and cause CIRRHOSIS , and will not reach the lung , so it will not compensate for Elastase secreted by activated macrophages causing PANLOBULAR EMPHYSEMA ..
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