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Old 02-14-2011
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Immunology Immunology Question about Rh Incompatibility

25-yo woman (type A, Rh-negative) gives birth to a type A, Rh-positive newborn. Which of the following should be administered to the mother immediately after the birth to prevent hemolytic disease of the newborn in future children?

A) Active immunization to induce anti-Rh IgG Abs
B) Active immunization to induce anti-Rh IgM Abs
C) Active immunization to remove Rh Ag
D) Passive immunization to remove Rh Ag
E) Treatment with corticosteroids
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Old 02-14-2011
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Answer is D.
First, there is no active immunization in this disease. We give Anti-Rh antibodies to mother to block and, thus, remove fetal Rh antigens from mother. With no antigens in maternal circulation, her immune system is not activated and future children are protected. we give passive immunization to mother to remove fetal Rh Ag.
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Old 02-14-2011
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this q in NBME 6.
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Old 02-14-2011
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I think answer is D...because with passive immunization..feedback inhibition prevent process of production and further sensitization of immune cell..so that risk is reduced in same as well as next births...coz production of Ig is inversely proportional to its serum concentration
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Old 02-14-2011
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the answer is D.
Rh antigen transferred through placenta in the maternal circulation during the process of delivery is neutralised by passive iso-immunization (anti-rh antibody) and prevents sensitization by mother to Rh antigen., resulting in no complications in her future pregnancies due to incompatibility!
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Old 02-14-2011
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Yeah definitely D,
Active immunization will actually sensitize the mom to Rh antigen and may cause a disaster in case the subsequent pregnancy is Rh positive.
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