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Old 02-19-2011
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Kidney How does hyperuricosuria increases Oxalate stone formation

hyperuricosuria causes formation of oxalate stones. pl can anyone explain the mechanism, how ?
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Old 02-19-2011
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In cases where volume of urine is significantly reduced or if abnormally high amounts of crystal-forming salts are present (hyperuricosuria) the concentration levels reach the point at which the salts no longer dissolve, so they precipitate out and form crystals.
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Old 02-19-2011
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yea right. but shoudnt then uric acid stones be formed ? y oxalate stones ? didnt get that.
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Hyperuricosuria is defined as urinary uric acid levels that exceed 800 mg/day in men and 750 mg/day in women. The most common cause of hyperuricosuria is increased dietary purine intake, but many other hereditary or acquired factors (eg, gout) may result in this condition. Individuals with hyperuricosuria may develop uric acid or calcium oxalate stones due to supersaturation of urine with monosodium urate. Monosodium urate may initiate calcium oxalate stone formation by the induction of heterogeneous nucleation or by absorption of certain inhibitors. Patients with calcium oxalate stones have a urinary pH of greater than 5.5.

Reference:
http://emedicine.medscape.com/article/444866-overview
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Old 02-19-2011
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hey thanku so much
but still i dont get one thing, if oxalate stones are formed when ph > 5 n uric acid decreases pH, how they form ! from that link i think maybe somehow monosodium urate must be increasing urinary pH.
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Old 02-19-2011
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Quote:
Originally Posted by namita View Post
hey thanku so much
but still i dont get one thing, if oxalate stones are formed when ph > 5 n uric acid decreases pH, how they form ! from that link i think maybe somehow monosodium urate must be increasing urinary pH.
Uric acid decreases urine PH but when you have oxalate stones in urine (which are formed because of the presence of monosodium urate) the urine PH goes high even though the patient is having hyperuricosuria.
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Old 02-19-2011
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Or maybe: at a urine pH <5.5 hyperuricosuric patients are more likely to form uric acid stones, and at a urine pH >5.5 hyperuricosuric patients are more likely to form calcium stones?
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Old 02-20-2011
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@mondoshawan, yea possible. i dont know, thats y i posted. i asked few of my friends, no one was actually kinda sure. il try to look up sm place else. u try too.
n hey i read ur ques that alpha 1 antitrypsin one, it was good one !
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Old 05-28-2015
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http://www.mayomedicallaboratories.c...nes/2a-22.html
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