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Old 04-06-2014
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Help help me with this uworld explanation please

please someone explain this.

FLUTAMIDE is a androgen receptor blocker.
uworld says that if flutamide is used as monotherapy
it causes a gradual effect of increasing testosterone levels
due to negative feedback.
this effect is reduced by the simultaneous administration of GNRH agonists

this is where i say WTF??

isnt supposed that the administration of GNRH agonists cause to release more testosterone?
and therefore complicate our prostate cancer patient??
how is this supposed to "help" the increased levels of testosterone 2ndary to
flutamide monotherapy to decrease them???

please someone enlighten me with this explanation from uworld
cant move forward!!! grrrr...
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  #2  
Old 04-06-2014
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OMG this is so funny, i came to my answer

GnRH in continuous fashion WORKS AS AN ANTAGONIST.
how silly of me

im having a rough sunday guys
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Old 04-06-2014
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yeah exactly i was abt to write that until i saw ur other post lol .. GnRH given continuously in prostate CA & fibroids & precocious puberty
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