Lyonization and twin disease occurance - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 02-23-2011
USMLE Forums Scout
Steps History: Not yet
Posts: 24
Threads: 5
Thanked 32 Times in 16 Posts
Reputation: 42
Genetics Lyonization and twin disease occurance


Is my understanding correct that Lyonization (random X inactivation) would explain the difference in two female twins- one expressing Duchennes (or any X-recessive disease for that matter) and the other not having the disease?

I read an article that states that uniparental disomy would explain twin differences in disease genetics also...

Yet I have seen questions with both choices in the answer, can someone please help explain this?

Thanks =)
Reply With Quote Quick reply to this message

Old 02-23-2011
USMLE Forums Addict
Steps History: 1 + CK
Posts: 116
Threads: 7
Thanked 343 Times in 94 Posts
Reputation: 353

if disease is x-linked, consider lyonization. if autosomal, consider uniparental disomy.
Reply With Quote Quick reply to this message
The above post was thanked by:
aktorque (02-23-2011), pnreddy (02-23-2011)



Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
PT PTT in Liver Disease? markstroke USMLE Step 1 Forum 3 08-01-2016 07:40 AM
Crohns disease FSUSTC USMLE Step 2 CK Forum 10 04-01-2011 12:23 AM
Plummer Disease ManuHarish USMLE Step 2 CK Forum 5 01-19-2011 06:41 PM
CT of Huntington's Disease aungawa USMLE Step 1 Forum 2 08-24-2010 08:38 AM
Tay Sachs disease jackat1000 USMLE Step 1 Mnemonics 6 04-16-2010 08:38 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)