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Old 02-23-2011
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Genetics Lyonization and twin disease occurance


Is my understanding correct that Lyonization (random X inactivation) would explain the difference in two female twins- one expressing Duchennes (or any X-recessive disease for that matter) and the other not having the disease?

I read an article that states that uniparental disomy would explain twin differences in disease genetics also...

Yet I have seen questions with both choices in the answer, can someone please help explain this?

Thanks =)
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Old 02-23-2011
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if disease is x-linked, consider lyonization. if autosomal, consider uniparental disomy.
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The above post was thanked by:
aktorque (02-23-2011), pnreddy (02-23-2011)



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