Drug effects on cholesterol synthesis? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 02-25-2011
medico.in's Avatar
USMLE Forums Scout
 
Steps History: ---
Posts: 62
Threads: 25
Thanked 11 Times in 8 Posts
Reputation: 21
Drug Drug effects on cholesterol synthesis?

can any one tell wat is the effect of usage of statins and bile acid sequestrants on hepatic cholesterol synthesis?
Reply With Quote Quick reply to this message



  #2  
Old 02-25-2011
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Arrow

For bile acid sequestrants:


Bile acid-binding resins (cholestyramine, colestipol, colesevelam) work by binding to bile acid in the gastrointestinal tract, interfering with its enterohepatic circulation. LDL is reduced as a consequence, because hepatic cholesterol is consumed in the re-synthesis of bile acids, which in turn increases the uptake of LDL from the circulation. Bile acid production and secretion is increased 10-fold because of the interruption in the enterohepatic circulation of bile acids. Bile acid-binding agents increase the cholesterol content of bile, increasing the risk of gallstone formation. Fibrates also increase the cholesterol content of bile, and thus also increase the risk for gallstones. Both fibrates and bile acid-binding resins should be used with caution in patients with preexisting gallbladder disease.


Statins on the other hand (rosuvastatin, atorvastatin, simvastatin, lovastatin, pravastatin, and fluvastatin), they can lower LDL cholesterol by inhibiting the enzyme HMG-CoA reductase in the liver. They have less effect than the fibrates or niacin in reducing triglycerides and raising HDL-cholesterol. There is limited evidence to support the use of statins for primary prevention in people with low cardiovascular risk. The most common adverse side effects are raised liver enzymes and muscle problems (rhabdomyolysis).


hope this helps...
Reply With Quote Quick reply to this message
The above post was thanked by:
apx85 (02-25-2011), drgabroomunda (02-26-2011), Mondoshawan (02-25-2011)
  #3  
Old 02-25-2011
medico.in's Avatar
USMLE Forums Scout
 
Steps History: ---
Posts: 62
Threads: 25
Thanked 11 Times in 8 Posts
Reputation: 21
Default thanks

thank u but how can u explain this sentence quoted by u?
Bile acid-binding agents increase the cholesterol content of bile.
Reply With Quote Quick reply to this message
  #4  
Old 02-25-2011
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Arrow

Quote:
Originally Posted by medico.in View Post
thank u but how can u explain this sentence quoted by u?
Bile acid-binding agents increase the cholesterol content of bile.
Alright Here you go....

A bile acid deficiency in the intestine occurs when the enterohepatic circulation of bile acids is interrupted by Bile acid-binding agents (eg. colesevelam). This drug also lowering the cholesterol levels in the blood by increasing the amount of cholesterol secreted into bile. However, increasing the cholesterol synthesis and decreasing the bile acid sequestration thru enterohepatic circulation will put the patient in risk of forming gallstone.

Reply With Quote Quick reply to this message
The above post was thanked by:
medico.in (02-26-2011), Mondoshawan (02-25-2011)
  #5  
Old 02-26-2011
medico.in's Avatar
USMLE Forums Scout
 
Steps History: ---
Posts: 62
Threads: 25
Thanked 11 Times in 8 Posts
Reputation: 21
Default Thank u

Ok just help me ot in this
Is my understanding correct
Because of increased bile acid production from cholesterol hepatic cholesterol synthesis also increases is this right?
Reply With Quote Quick reply to this message
  #6  
Old 02-26-2011
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 590
Threads: 31
Thanked 1,227 Times in 410 Posts
Reputation: 1251
Thumbs Up

Quote:
Originally Posted by medico.in View Post
Ok just help me ot in this
Is my understanding correct
Because of increased bile acid production from cholesterol hepatic cholesterol synthesis also increases is this right?
That is right
Reply With Quote Quick reply to this message
The above post was thanked by:
aktorque (02-26-2011), medico.in (02-26-2011)



Reply

Tags
Pharmacology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Video - Cholesterol and other lipids in your blood... deyneko USMLE Step 1 Forum 1 12-11-2010 08:21 PM
question - lithium toxicity drug-drug interaction mtoi USMLE Step 1 Forum 5 10-31-2010 01:48 PM
nucleotide synthesis Androide89 USMLE Step 1 Forum 2 09-04-2010 11:03 PM
CSF:Synthesis and absorption jackat1000 USMLE Step 1 Mnemonics 0 01-27-2010 04:56 PM
Drug Side Effects! Gold-Turk USMLE Step 1 Forum 1 09-11-2009 10:48 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)