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Old 02-28-2011
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Drug Confusion about Flutamide and GnRH

It is mentioned that usage of Flutamide causes gradual increase in testosterone levels due to negative feed back mechanism......and also given usage of GnRH agonists can decrease this effect how is it possible?

my doubt is if flutamide increases testosterone, at the same time GnRH will also increase as part of the feed back loop then what is the role of GnRH agonists

anyone please help in this concept........
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Old 02-28-2011
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Arrow You'll find the answer here

Please read the following:
Prostatic Carcinoma Drug of choice
Prostate CA Rx
Some questions about flutamide
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Old 02-28-2011
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Correct Answer

Flutamide acts as a testosterone receptor antagonist; wheres as a GnRH analog such as Leuprolide (long term use) causes downregulation - hence it can cause medical castration in cancers, such as Prostate.

It is the function of GnRH long-acting drugs such as Leuprolide that cause downregulation, which aids in combating cancer.

As for physiology, it is correct that GnRH use would cause an increase in testosterone due to the increase in FSH/LH -- but its the specific use of long-term ability that is exploited here.
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Quote:
Originally Posted by shriman View Post
Flutamide acts as a testosterone receptor antagonist; wheres as a GnRH analog such as Leuprolide (long term use) causes downregulation - hence it can cause medical castration in cancers, such as Prostate.

It is the function of GnRH long-acting drugs such as Leuprolide that cause downregulation, which aids in combating cancer.

As for physiology, it is correct that GnRH use would cause an increase in testosterone due to the increase in FSH/LH -- but its the specific use of long-term ability that is exploited here.
thanks u so much for the help got very much confused with this thanks once again
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