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Old 03-03-2011
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Blood How come we have warm antibodies in CLL?

I'm not understanding how CLL is related to warm Ab autoimmune hemolytic anemia. Warm Ab = IgG but in CLL we don't have differentiated B cells so where is this IgG coming from?
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Old 03-03-2011
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Originally Posted by Zent & Kay 2010
Autoimmune cytopenia complicating CLL is usually caused by polyclonal T cell dependent mechanisms that result from the loss of self tolerance. The pathogenic antibodies responsible for about 90% of cases of AIHA and ITP are produced by non-malignant B cells and are polyclonal high affinity IgG directed against red blood cell (RBC) or platelet antigens. These antibodies can ligate antigens on RBC and platelets and the opsonized cells are then destroyed via an antibody dependent cellular cytotoxicity (ADCC) mechanism mediated predominantly by fixed macrophages in the spleen and liver.
This article makes it sound like the malignant CLL cells are acting as dysregulated antigen-presenting cells...
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