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  #1  
Old 04-16-2014
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Cool A difficult Question!!!

If you hate minutiae, then please stay away.....

Q) Your patient who has been receiving chemotherapy for Non-Hodgkin's Lymphoma for the past few months, has come to the you with a complaint of passing "RED" urine. He is admitted to Urology, where they irrigate the bladder with a drug and the patient eventually recovers. This drug also is used in which of the following?

A. As an antidote to B-Blocker overdose
B. In the prevention of glaucoma
C. As an anti-tussive
D. In the treatment of hypocalcaemia
E. In the management of Kartageners syndrome
F. In the diagnosis of Whipple's disease

I wrote this question and even I feel its pretty stupid.......
Nevertheless at the end of the day a fact is a fact.....
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  #2  
Old 04-16-2014
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management of kartageners
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  #3  
Old 04-17-2014
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management of kartagners.. you my friend are giving in to the dark side
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Old 04-17-2014
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Yep.............Its Kartageners.

Educational objective:

N-Acetyl cysteine is used as a mucolytic in COPD, Bronchiectasis, Tuberculosis, Cystic Fibrosis, Pneumonia..........

It is used in the treatment of Hemorrhagic cystitis.......

*** It is also used to prevent Contrast Nephropathy.
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Old 04-17-2014
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er... werent u talking about cyclophosphamide, and its hhgic cystitis mx with mesna??

mesna is also used as a mucolytic.
its a win-win either way though.
NAC is also used for hhgic cystitis, but mesna provides better urothelial protection...
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  #6  
Old 04-17-2014
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Quote:
Originally Posted by dr rookie View Post
er... werent u talking about cyclophosphamide, and its hhgic cystitis mx with mesna??

mesna is also used as a mucolytic.
its a win-win either way though.
NAC is also used for hhgic cystitis, but mesna provides better urothelial protection...
Thanks I was thinking ur way as well not knowing it was about the contrast nephropathy thing. But any way u get the answer correct.
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  #7  
Old 04-17-2014
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@ dr rookie

Yes.... You are correct about Mesna being more effective than NAC.

BUT...... Mesna has a more PROPHYLACTIC role........

Rather, some would argue that Mesna is not much beneficial after Hemorrhagic Cystitis has developed.....

*Treatment of H. cystitis would include:
1. Continuous bladder Irrigation with saline.
2. NAC (or Mesna) can be added to the above to enhance clot removal.
3. Antibiotic coverage
4. Surgery for refractory cases.

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Old 04-17-2014
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Quote:
Originally Posted by medstud. View Post
@ dr rookie

Mesna is not much beneficial AFTER Hemorrhagic Cystitis has developed.....

ah!... the key word. AFTER.
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