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Old 03-05-2011
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Biochemistry Collagen Synthesis vitamin C and copper as cofactors

Just wondering,
Does proline hydroxylase and lysine hydroxylase require both Vitamin C and Copper as there co enzyme for collagen synthesis ?
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Old 03-05-2011
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Collagen crosslinking does require both, but at different enzymes.

Prolyl hydroxylase and lysyl hydroxylase require vitamin C and iron as cofactors. Lysyl oxidase deaminates lysine and hydroxylysine in the first step for collagen crosslinking, and this requires copper (hence the hair and skin signs in Menkes disease).

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