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Old 03-06-2011
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Arrow Electron Micro of a cell- diagnosis

Look into the structure very carefully and find any abnormal activity of the cell.

Electron Micro of a cell- diagnosis-em-cell.jpg
click image to enlarge

case: 55 y/o male with long history of proteinuria. Biopsy of his bone marrow has shown above (electron micro pic). Diagnosis?
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Old 03-06-2011
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Nice question! Looks like a plasma cell - was that Bence-Jones proteinuria, by any chance?
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Old 03-06-2011
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Wow...Mondoshawan! you got it!... I know you knew it. Can you tell me what abnormal activity is going on in the cell! i mean something unwanted thing is happening.... can you identify it?
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Old 03-06-2011
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No - I can't see the abnormality. It looks active, but that's all I can tell... Looking forward to the explanation!
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Old 03-06-2011
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Quote:
Originally Posted by aktorque View Post
Wow...Mondoshawan! you got it!... I know you knew it. Can you tell me what abnormal activity is going on in the cell! i mean something unwanted thing is happening.... can you identify it?
Too many rough endoplasmic reticulum; too much antibody synthesis. One more clue is clock-face heterochromatin; aligned around the periphery of the nucleus.
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Old 03-06-2011
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Originally Posted by drahmednawaz View Post
Too many rough endoplasmic reticulum; too much antibody synthesis. One more clue is clock-face heterochromatin; aligned around the periphery of the nucleus.
Yes you are correct...

There are too many RER doing overtime, producing immunoglobulin proteins and antibodies.

Dr.Goljan mentioned on his audio lecture about this electron microscopic picture of an abnormal plasma cell. This is a typical EM plasma cell you'll see in multiple myeloma pt. He also mentioned about the AL type amyloidosis on EM, but I couldn't find any slides on the net.

Anyway, for the exam, you should b familiar with EM, LM and Fluorescent slides.
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Cell-Biology-, Micrographs-, Pathology-, Renal-, Step-1-Questions

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