Can't understand the effect of uncouplers on Electron Transport Chain! - USMLE Forums
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Old 03-07-2011
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Help Can't understand the effect of uncouplers on Electron Transport Chain!

In Electron transport Chain :

Uncouplers decrease proton gradient and decrease ATP synthesis > pretty logical

but why do they INCREASE oxygen consumption & INCREASE NADH oxidation & INCREASE rate of ETC ???
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Old 03-07-2011
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In ETC, the FADH2 & NADH are oxidized to produce H+ which are combined with Oxygen to produce H2O & the energy produced is utilized to produce ATPs.

Uncouplers let the oxygen combine with H+ without the formation of ATP, so there is no ATP production but all the other reactions keep on going.
Dec. ATP production will also inc. the rate of reactions of Glycolysis & TCA cycle.
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