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Old 03-10-2011
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Neuro A Brian Biopsy Question

A 75-year-old woman has had progressively worsening mental function, as indicated by her son when he brings his mother to see you. The son states that his mother is now frequently getting lost in the neighborhood. He relates that she cannot easily feed or dress herself. She often does not seem to know who she is. After a year-long course in a nursing home, she dies from a respiratory infection. The brain at autopsy weighs 1025 gm and demonstrates frontal and parietal atrophy, with ex vacuo ventricular dilation. The light microscopic appearance of the frontal cortex is seen below with Bielschowsky silver stain.

A Brian Biopsy Question-brainbiopsy.jpg
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Which of the following statements best characterizes this woman's disease?

A. A bloodborne pathogen led to this illness
B. An amyloid angiopathy can be present
C. Inheritance occurs in an autosomal dominant fashion
D. Response to dopaminergic agents often occurs
E. Aluminum toxicity explains these findings
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Old 03-10-2011
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i relate this wid amyloid deposition in elderly, B...
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Old 03-10-2011
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Arrow B) An amyloid angiopathy can be present

My ans is B) An amyloid angiopathy can be present

I see both amyloid plaques and neurofibrillary tangles on this slide. Amyloid-beta proteins are more visible on congo red stain.

A Brian Biopsy Question-amyloid.jpg
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Old 03-10-2011
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This is the clue if you don't know what exactly is shown in this slide-Bielschowsky silver impregnation can be used as a single stain for the diagnosis of Alzheimer's disease. It impregnates both the amyloid and neuritic components of the senile plaques and it reliably stains neurofibrillary tangles.

Yes. B. Amyloid plagues and neurofibrillary tangles
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Quote:
Originally Posted by 1TA2B View Post
This is the clue if you don't know what exactly is shown in this slide-Bielschowsky silver impregnation can be used as a single stain for the diagnosis of Alzheimer's disease. It impregnates both the amyloid and neuritic components of the senile plaques and it reliably stains neurofibrillary tangles.

Yes. B. Amyloid plagues and neurofibrillary tangles
Awesome, that's exactly what I thought of, but the Bielschowksy silver staining threw me off, since I remembered majority of the time they used Congo Red for amyloid.
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Default Correct Answer: B

It is a histologic feature of AD disease
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Old 03-11-2011
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ans s D............
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