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Old 10-30-2009
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Drug Tricky Question; Drug causing this baby problem

A pregnant female did ultrasound and it was reported as the baby is having a fluid sac on the lower back. What medication could exacerbate the dietary deficiency responsible for the this defect?

a- Carbamazepine
b- Co trimaxazole
c- Lithium
d- Valproic Acid
e- Captopril

Ok guys let's see who'll get the question right
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Old 10-30-2009
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Quote:
Originally Posted by cordoba View Post
A pregnant female did ultrasound and it was reported as the baby is having a fluid sac on the lower back. What medication could exacerbate the dietary deficiency responsible for the this defect?

a- Carbamazepine
b- Co trimaxazole
c- Lithium
d- Valproic Acid
e- Captopril

Ok guys let's see who'll get the question right
I think it is NTD caused by folate deficiency..
From interfering the dietary folate absorption and associated with NTD , most likely the drug will be anticonvulsant...
So i chose valproic acid as it is a teratogenic anticonvulsant causing NTD
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Quote:
Originally Posted by smile135 View Post
I think it is NTD caused by folate deficiency..
From interfering the dietary folate absorption and associated with NTD , most likely the drug will be anticonvulsant...
So i chose valproic acid as it is a teratogenic anticonvulsant causing NTD
Correct!

How did you know that!

Why not co trimaxazole, isn't it anti folate?
Why not carbmazepine, it also causes spina bifida?
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Old 10-30-2009
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Quote:
Originally Posted by cordoba View Post
Why not co trimaxazole, isn't it anti folate?
Sulfonamides inhibit folate synthesis in bacteria not humans
human do not make folate
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Old 10-30-2009
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Quote:
Originally Posted by cordoba View Post
Correct!

How did you know that!

Why not co trimaxazole, isn't it anti folate?
Why not carbmazepine, it also causes spina bifida?

For cotrimazole. it inhibits folate syn: in bacteria and not in human ...
for carbamazepine, it stays 2nd compared to valproic acid although there is association with NTD.
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Old 05-09-2013
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valpraoic acid and phenytoin inhibit the intestinal conjugases which are responisble for folic acid absorption
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The above post was thanked by:
faisalahmed518 (09-20-2014)



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