Leukocyte Adhesion Defect Types?

drsmar · #1 10-30-2009

Hey I've seen a question about Leukocyte Adhesion Defect in NBME and the options were talking about LAD1 and LAD2! What are these did not see them in Kaplan or FA?

Any help would be appreciated

StepTaker · #2 10-31-2009

Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß2 subunit of LFA1 family (ß2 integrins). These are known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium).

Leukocyte adhesion deficiency type II (LAD II) is extremely rare. It is a defect in selectins types E and P expressed on endothelial cells, and also sialyl Lewis-X expressed on leukocytes.

Rookie · #3 03-20-2012

It's given in Kaplan notes, but they haven't mentioned the types of it..

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