Calcium and Constipation - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 03-12-2011
nicki's Avatar
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 109
Threads: 27
Thanked 39 Times in 33 Posts
Reputation: 49
Question Calcium and Constipation

I keep reading calcium causes constipation but what is the mechanism?
Reply With Quote Quick reply to this message



  #2  
Old 03-13-2011
nicki's Avatar
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 109
Threads: 27
Thanked 39 Times in 33 Posts
Reputation: 49
Default

Anyone know?
Reply With Quote Quick reply to this message
  #3  
Old 03-13-2011
USMLE Forums Scout
 
Steps History: Not yet
Posts: 19
Threads: 7
Thanked 18 Times in 7 Posts
Reputation: 28
Default

Significant hypercalcemia (serum calcium level >12 mg/100 mL) can slow bowel. (has to do with the intrinsic pathways inside the smooth muscle fibers probably) This happens especially when taking calcium supplements.
Hypokalemia can cause a paralytic ileus too.

In addition to constipation, prolonged hypercalcemia tends to cause high gastrin levels, which may contribute to peptic ulcer disease and may lead to pancreatitis or the deposition of calcium in any soft tissue.

Please tell me if this helps
Reply With Quote Quick reply to this message
The above post was thanked by:
Mondoshawan (03-13-2011)
  #4  
Old 03-13-2011
USMLE Forums Scout
 
Steps History: Not yet
Posts: 19
Threads: 7
Thanked 18 Times in 7 Posts
Reputation: 28
Default

HYPERcalcemia: raises threshold for action potential -> decreased contraction -> constipation

QFT
Reply With Quote Quick reply to this message
The above post was thanked by:
Mondoshawan (03-13-2011), pkul85 (11-20-2013)
  #5  
Old 03-13-2011
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 590
Threads: 31
Thanked 1,227 Times in 410 Posts
Reputation: 1251
Default

hypercalcemia also --> polyuria, so I'm sure the dehydration makes any constipation worse..
Reply With Quote Quick reply to this message
  #6  
Old 03-13-2011
USMLE Forums Guru
 
Steps History: Not yet
Posts: 298
Threads: 45
Thanked 713 Times in 210 Posts
Reputation: 723
Default

According to UptoDate:

Hypercalcemia: GI symptoms, such as constipation, anorexia, and nausea occur commonly. Constipation may be related to decreased smooth muscle tone and/or abnormal autonomic function.

Looks like the mechanism is not very clear
Reply With Quote Quick reply to this message
The above post was thanked by:
drgabroomunda (05-22-2011), Mondoshawan (03-13-2011)
  #7  
Old 03-13-2011
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 82
Threads: 8
Thanked 114 Times in 49 Posts
Default

I also couldn't find, why hypercalcemia causes lethargy & constipation.

Explanation by @fernandbteich may explain it but i am not sure....

Quote:
Originally Posted by Mondoshawan View Post
hypercalcemia also --> polyuria, so I'm sure the dehydration makes any constipation worse..
Hypercalcemia cause polyuria by antagonizing the effects of ADH & due to osmotic diuresis.
__________________
Will you look back on life and say, "I wish I had," or "I'm glad I did
Reply With Quote Quick reply to this message
The above post was thanked by:
Mondoshawan (03-13-2011)
  #8  
Old 03-13-2011
USMLE Forums Addict
 
Steps History: Not yet
Posts: 125
Threads: 50
Thanked 29 Times in 20 Posts
Reputation: 39
Default

OK..now i am confused

Calcium channel blockers (verapamil) cause constipation..i thought it was because calcium is needed for contraction of smooth muscle cells hence when blocked >> reduced contraction > constipate

Ofcourse my logic has been bombed now, would some one CLARIFY ??
Reply With Quote Quick reply to this message
  #9  
Old 03-13-2011
nicki's Avatar
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 109
Threads: 27
Thanked 39 Times in 33 Posts
Reputation: 49
Default

Yes this is indeed a hard concept but thanks everyone for trying to explain it as its so important to know why each side effect occurs.
Reply With Quote Quick reply to this message



Reply

Tags
Gastrointestinal-Tract-, Physiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Black Stool + Constipation OR Diarrhea rasheed USMLE Step 2 CK Classic Clues 3 07-09-2016 12:58 PM
Calcium, Magnesium, and Ferric Iron absorption sites! laxitjn USMLE Step 1 Forum 1 01-28-2011 08:50 AM
Extracellular Calcium needed for cardiac muscle dr z USMLE Step 1 Forum 2 10-29-2010 04:05 PM
Use of calcium channel blocker in CHF step1an USMLE Step 1 Forum 9 08-19-2010 07:42 AM
NE + G proteins = increased intracellular calcium Seetal USMLE Step 1 Forum 6 04-29-2010 01:00 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)