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  #1  
Old 04-29-2014
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Default ADH

Does anybody knows about any lung pathology associated with increased vasopressin ( aka ADH ) ?
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  #2  
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Quote:
Originally Posted by ANUBHAV View Post
Does anybody knows about any lung pathology associated with increased vasopressin ( aka ADH ) ?

small cell ca of lung-paraneoplastic syndrome
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  #3  
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Originally Posted by score250+ View Post
small cell ca of lung-paraneoplastic syndrome
Can you explain ? How ?
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Default adh

cells makes ash
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  #5  
Old 04-29-2014
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How does an increase in ADH cause hyponatremia and cerebral edema ?
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Old 04-30-2014
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ADH is made in hypothalamus
Stored and released from posterior pituitary
Action of ADH - retain water by increasing h20 permeability in collecting duct
NOTE - WATER follows Na but not vice versa so here water reabsorption is with the help of UREA(+) so ADH no role in reabsorption of Na(electrolytes)
This is the reason why hyponatremia occurs which can lead to cerebral edema
I hope this helps you
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Quote:
Originally Posted by synaptobrevin View Post
ADH is made in hypothalamus
Stored and released from posterior pituitary
Action of ADH - retain water by increasing h20 permeability in collecting duct
NOTE - WATER follows Na but not vice versa so here water reabsorption is with the help of UREA(+) so ADH no role in reabsorption of Na(electrolytes)
This is the reason why hyponatremia occurs which can lead to cerebral edema
I hope this helps you
I am not able to project how hyponatremia can lead to cerebral edema ?
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Old 04-30-2014
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Quote:
Originally Posted by ANUBHAV View Post
I am not able to project how hyponatremia can lead to cerebral edema ?
When you hyponatremic, your brain tissue will be hypertonic. The water will flow out of the vessels into the brain = edema.

Good luck!
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Quote:
Originally Posted by Heisenberg View Post
When you hyponatremic, your brain tissue will be hypertonic. The water will flow out of the vessels into the brain = edema.

Good luck!
Thanks ..
actually I was not thinking it can be simply because of osmosis.
and also if it is hyponatremia , it shud resultninto generalised edema..why only cerebral edema?
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Quote:
Originally Posted by ANUBHAV View Post
Thanks ..
actually I was not thinking it can be simply because of osmosis.
and also if it is hyponatremia , it shud resultninto generalised edema..why only cerebral edema?
I think it has to do with how quickly the brain can respond to the hyponatremia... See below.

"Animal experiments have facilitated analysis of the probable causes of brain edema in severe acute hyponatremia. That work demonstrated that brain cells have the ability to adapt to hypo-osmolality-induced cell swelling, as do most other cells (17). However, this process requires 48 to 72 h to reach completion (17). An initial phase of rapid extrusion of ions (Na+, K+, and Cl-) from the cells is followed by a slow phase, during which the intracellular concentrations of osmotically active organic osmolytes are reduced (18,19). This regulatory process serves to return the initially swollen cells to normal cell volume. During the transitional phase, i.e., before cell volume adaptation is complete, brain edema is present. Because of the rigid skull surrounding the brain, cerebral edema can lead to decreased brain perfusion and herniation of the brainstem into the foramen magnum. These changes are preventable by rapid correction of the acute severe hyponatremia. Acute severe hyponatremia is usually a medical emergency. It causes brain edema, which is demonstrable by computed tomography (CT) or magnetic resonance imaging (MRI). It should be rapidly corrected, to prevent permanent brain damage or even worse consequences."

I found this in the JASN, "Treatment of Severe Hyponatremia: Conventional and Novel Aspects"
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  #11  
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Quote:
Originally Posted by synaptobrevin View Post
ADH is made in hypothalamus
Stored and released from posterior pituitary
Action of ADH - retain water by increasing h20 permeability in collecting duct
NOTE - WATER follows Na but not vice versa so here water reabsorption is with the help of UREA(+) so ADH no role in reabsorption of Na(electrolytes)
This is the reason why hyponatremia occurs which can lead to cerebral edema
I hope this helps you
I figured it out to be dilutional hyponatremia..
thanks
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Old 04-30-2014
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Quote:
Originally Posted by ANUBHAV View Post
Thanks ..
actually I was not thinking it can be simply because of osmosis.
and also if it is hyponatremia , it shud resultninto generalised edema..why only cerebral edema?
ONLY hyponatremia without sodium overload (no edema) due to the SODIUM escape, lets not forget that concept.
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Originally Posted by drpisho View Post
ONLY hyponatremia without sodium overload (no edema) due to the SODIUM escape, lets not forget that concept.
Sorry , I couldn't get you..
please explain buddy..
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