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Old 05-06-2014
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Default loop diuretics and decreased absorption of ca and mg

I'm really confused about loop diuretics.

Loop diuretics inhibit the Na/K/2Cl transporter and decrease the positive potential, causing Mg and Ca to be lost.

I know Na, K, and Cl are not reabsorbed simply because loop diuretics directly block that pump, but how do loop diuretics cause Mg and Ca to be lost? Does it have to do with the loss of positive potential? Please guys if anyone knows, please explain.
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Old 05-06-2014
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Quote:
Originally Posted by britesky89 View Post
I'm really confused about loop diuretics.

Loop diuretics inhibit the Na/K/2Cl transporter and decrease the positive potential, causing Mg and Ca to be lost.

I know Na, K, and Cl are not reabsorbed simply because loop diuretics directly block that pump, but how do loop diuretics cause Mg and Ca to be lost? Does it have to do with the loss of positive potential? Please guys if anyone knows, please explain.
Since mg& ca are absorbed indirectly through + luminal potential created by K back leak . When there is no k back leak as with loop diuretics, there would be lost of ca and mg as well. Plus in the basolateral side of the cells there is Na/K pump. This pump drives the k in to the tubular cells to so the concentration of k rises in order to leak back and in return take Na out to ECF. if there is less Na in the tubular cell as with diuretics the Na/k pump would not work in the basolateral side.
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