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High Yield Question #5

3K views 10 replies 6 participants last post by  aktorque 
#1 ·
Which of the following is a major core protein of the human immunodeficiency virus encoded by the HIV gag gene?

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A) GP 120
B) GP 41
C) P 21
D) P 17
E) P 7
 
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#2 ·
p17


gag is one of the three "main" genes found in all retroviruses (along with env and pol). It contains around 1500 nucleotides, and encodes four separate proteins which form the building blocks for the viral core:
Capsid protein, CA, p24
Matrix protein, MA, p17 (this protein isn't actually part of the viral core but the "matrix" which anchors the core to the viral envelope)
Nucleocapsid protein, NC, p9
p6
The most significant role of the gag gene is therefore to encode important proteins which will make up the viral core.
 
#4 ·
p17

gag is one of the three "main" genes found in all retroviruses (along with env and pol). It contains around 1500 nucleotides, and encodes four separate proteins which form the building blocks for the viral core:
Capsid protein, CA, p24
Matrix protein, MA, p17 (this protein isn't actually part of the viral core but the "matrix" which anchors the core to the viral envelope)
Nucleocapsid protein, NC, p9
p6
The most significant role of the gag gene is therefore to encode important proteins which will make up the viral core.
viral core (or capsid)

you have the information but the ans is incorrect (sorry). The qn is asking for viral core protein?
 
#7 ·
p24 is a major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.

I'm not sure about P7 and P17 are part of core protein (capsid protein) . They also encoded by GAG gene, but they don't create core proteins instead nucleocapsid protein and matrix protein respectively.

Major core proteins are present in HIV-1 p24 and HIV-2 p26.
 
#8 ·
p24 is a major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.

I'm not sure about P7 and P17 are part of core protein (capsid protein) . They also encoded by GAG gene, but they don't create core proteins instead nucleocapsid protein and matrix protein respectively.

Major core proteins are present in HIV-1 p24 and HIV-2 p26.
BUt in ans its not mentioned ????
C=p21 ???:confused:
 
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