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Old 04-02-2011
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Arrow High Yield Question #5

Which of the following is a major core protein of the human immunodeficiency virus encoded by the HIV gag gene?

High Yield Question #5-hiv001.gif
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A) GP 120
B) GP 41
C) P 21
D) P 17
E) P 7
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Old 04-02-2011
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p17


gag is one of the three "main" genes found in all retroviruses (along with env and pol). It contains around 1500 nucleotides, and encodes four separate proteins which form the building blocks for the viral core:
Capsid protein, CA, p24
Matrix protein, MA, p17 (this protein isn't actually part of the viral core but the "matrix" which anchors the core to the viral envelope)
Nucleocapsid protein, NC, p9
p6
The most significant role of the gag gene is therefore to encode important proteins which will make up the viral core.
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Old 04-02-2011
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Quote:
Originally Posted by aktorque View Post
which of the following is a major core protein of the human immunodeficiency virus encoded by the hiv gag gene?



a)gp 120
b)gp 41
c)p 21
d)p 17
e)p 7
d)p 17.....
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Old 04-02-2011
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Quote:
Originally Posted by bronchiole View Post
p17


gag is one of the three "main" genes found in all retroviruses (along with env and pol). It contains around 1500 nucleotides, and encodes four separate proteins which form the building blocks for the viral core:
Capsid protein, CA, p24
Matrix protein, MA, p17 (this protein isn't actually part of the viral core but the "matrix" which anchors the core to the viral envelope)
Nucleocapsid protein, NC, p9
p6
The most significant role of the gag gene is therefore to encode important proteins which will make up the viral core.
viral core (or capsid)

you have the information but the ans is incorrect (sorry). The qn is asking for viral core protein?
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Old 04-02-2011
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Quote:
Originally Posted by aktorque View Post
viral core (or capsid)

you have the information but the ans is incorrect (sorry). The qn is asking for viral core protein?


no need to be sorry...
i am hitting the bottom fastest ever...
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Old 04-02-2011
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it's p7 but i was searching for p24 also !
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p24 is a major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.

I'm not sure about P7 and P17 are part of core protein (capsid protein) . They also encoded by GAG gene, but they don't create core proteins instead nucleocapsid protein and matrix protein respectively.

Major core proteins are present in HIV-1 p24 and HIV-2 p26.
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Old 04-03-2011
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Quote:
Originally Posted by aktorque View Post
p24 is a major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.

I'm not sure about P7 and P17 are part of core protein (capsid protein) . They also encoded by GAG gene, but they don't create core proteins instead nucleocapsid protein and matrix protein respectively.

Major core proteins are present in HIV-1 p24 and HIV-2 p26.

BUt in ans its not mentioned ????
C=p21 ???
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Old 04-03-2011
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Originally Posted by rah_mem View Post
BUt in ans its not mentioned ????
C=p21 ???
Oh... mam.. I'm sooo sooorrry. I put the wrong choice. Thanks to rah_mem to point out my mistake.

A)GP 120
B)GP 41
C)P 24
D)P 17
E)P 7

Choice C) p24 is correct not P21(its not exist I guess.) I'm really sorry about that. Next time I'll double check the ans b4 I post it on.
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Old 04-03-2011
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Quote:
Originally Posted by aktorque View Post
Oh... mam.. I'm sooo sooorrry. I put the wrong choice. Thanks to rah_mem to point out my mistake.

A)GP 120
B)GP 41
C)P 24
D)P 17
E)P 7

Choice C) p24 is correct not P21(its not exist I guess.) I'm really sorry about that. Next time I'll double check the ans b4 I post it on.
Whew! That had me a bit frazzled...I was like they are asking stuff that I've never even heard of lol. Makes me feel a lot better that it's p24
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Originally Posted by heights View Post
Whew! That had me a bit frazzled...I was like they are asking stuff that I've never even heard of lol. Makes me feel a lot better that it's p24
I know... I made you confuse... :sorry:
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