The Pathophysiologic Basis of Malignant Hyperthermia - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 04-06-2011
kemoo's Avatar
USMLE Forums Guru
 
Steps History: 1+CK+CS
Posts: 378
Threads: 161
Thanked 103 Times in 52 Posts
Reputation: 117
Question The Pathophysiologic Basis of Malignant Hyperthermia

what cause malignant hyperthermia after anesthesia ?


A- increase release of ca from sarcoplasmic reticulum

B- genetic variation of pseudocholinestrase enzyme ?
Reply With Quote Quick reply to this message



  #2  
Old 04-07-2011
good_boy_1234's Avatar
USMLE Forums Master
 
Steps History: 1 + CS
Posts: 546
Threads: 91
Thanked 320 Times in 145 Posts
Reputation: 366
Default

I guess it is A....So increase muscle contractions & heating
I think B causes Scoline (succinylcoline or suxmethonium) Apnea
Reply With Quote Quick reply to this message
  #3  
Old 04-07-2011
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,175
Threads: 38
Thanked 852 Times in 478 Posts
Reputation: 862
Default

Yep, I will also go with A..

Tx with Dantrolene.
Reply With Quote Quick reply to this message
 
  #4  
Old 04-07-2011
USMLE Forums Scout
 
Steps History: Not yet
Posts: 11
Threads: 2
Thanked 12 Times in 5 Posts
Reputation: 22
Default

Answer is A. malignant hyperthermia occurs after administration of halothane, due to abnormal Ca release...Treatment is with dantrolene.

pseudocholine esterase causes prolonged succinylcholine apnoea...
Reply With Quote Quick reply to this message
  #5  
Old 04-07-2011
bebix's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,357
Threads: 194
Thanked 3,261 Times in 881 Posts
Reputation: 3271
Default

Quote:
Originally Posted by vansha View Post
Answer is A. malignant hyperthermia occurs after administration of halothane, due to abnormal Ca release...Treatment is with dantrolene.

pseudocholine esterase causes prolonged succinylcholine apnoea...
The problem is with the ryanodine receptor => genetic => plenty of Ca (different to "genetic variation of pseudocholinestrase enzyme" )
and you could also induce a crisis not only with volatile anesthetic agents (halothane, sevo....), but also with depolarizing neuromuscular blocker (succinylcholine)....
Reply With Quote Quick reply to this message
The above post was thanked by:
melboghdady (07-07-2013)



Reply

Tags
Pathology-, Physiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Molecular Basis of Pain in Myocardial Infarction? khushboo USMLE Step 1 Forum 1 10-22-2010 06:26 AM
Biochemical Basis of this Scenario Yallah USMLE Step 1 Forum 3 04-19-2010 06:56 AM
Histology grading: Benign or Malignant? Farazdaq USMLE Step 1 Forum 2 02-23-2010 08:07 AM
immunological basis question DrSeddik USMLE Step 1 Forum 6 02-07-2010 10:34 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)