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Old 04-10-2011
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Biochemistry Practice question; Gluconeogenesis

Gluconeogenesis is an extremely important reaction carried out in hepatocytes allowing for glucose homeostasis in the blood. The primary positive control of hepatic gluconeogenesis is exerted by which of the following?

(A) high acetylcoenzyme A (acetyl-CoA) levels
(B) high adenosine triphosphate (ATP) levels
(C) high citrate levels
(D) low ATP levels
(E) low citrate levels
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Old 04-10-2011
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The answer is A.

Acetyl-CoA is the obligate activator of pyruvate carboxylase which converts pyruvate to oxaloacetate. Acetyl-CoA also inhibits pyruvate dehydorgenase to prevent the breakdown of pyruvate to acetyl-CoA thus increasing the availability of pyruvate as substrate for gluconeogenesis.
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Old 04-11-2011
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Correct, the answer is A
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