Regarding mTOR pathway - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 05-17-2014
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 592
Threads: 92
Thanked 196 Times in 128 Posts
Reputation: 206
Send a message via Skype™ to drpisho
Question Regarding mTOR pathway

Hi guys, just 2quick questions

1does IL2 additionally of using JAK/STAT Pathway, also uses mTOR??

2who uses mTOR pathway??

i get confused because Sirolimus inhibits mTOR, and sirolimus STOPS proliferation of Tcells by blocking IL2 ligand binding to them.
does this mean that IL2 uses ALSO mTOR pathway??

please help out im confused
__________________
Will. Power. Faith. MATCHED IM 2016!
Reply With Quote Quick reply to this message
The above post was thanked by:
sm3356 (06-27-2015)



  #2  
Old 05-18-2014
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 91
Threads: 7
Thanked 47 Times in 27 Posts
Reputation: 57
Default Sirolimus

You've raised a good point. This is what I found on d net. Kinda irritating it is. I'mI'm not able to copy paste the data. In short, what they said was that mtor inhibits the il2 action of depleting cdk cyclin inhibition , to cause growth at G1- S phase transition.
But no where did they mention about mtor being the tyrosine kinase pathway.
I've got another doubt. Isn't ras also in the tyrosine kinase pathway.
Reply With Quote Quick reply to this message
  #3  
Old 05-18-2014
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 91
Threads: 7
Thanked 47 Times in 27 Posts
Reputation: 57
Default

Yo! Got it.
Tyrosine kinase n Janus kinase are pretty much the same .both are dimers. Tyrosine kinase has intrinsic activity whereas Janus kinase doesn't. Egs under tyr kinase are insulin and growth factors and under janus kinase are GH, prolactin, cytokines, erythropoeitin and colony stimulating factors.
Now coming to the point. Tyrosine kinase pathway activates Ras pathway (mapkinase) and pip3 pathway( → akt → mtor ) which increase translocation of glut 4 to the cell memb , cause growth by acting in the nucleus and causing transcription.
Janus kinase has no intrinsic activity but it recruits tyrosine kinase. So apart from activating STAT( signal transducer and activator of transcription) it also activates the ras pathway and pip3(→mtor ).
All the examples mentioned help in growth so they must be having common pathways na.
Hope this clarified your doubt
Reply With Quote Quick reply to this message
The above post was thanked by:
DrNewB (09-02-2014), Romaniv (12-06-2016), sm3356 (06-27-2015)



Reply

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Coagulation pathway Umesh USMLE Step 1 Forum 1 03-13-2014 09:11 AM
lacrimal pathway medicalbiology USMLE Step 1 Forum 2 06-01-2013 02:27 PM
Which signaling pathway? hoor USMLE Step 1 Forum 2 09-26-2012 02:59 PM
My pathway to get 99/256 dr_smilingtears USMLE Step 1 Forum 10 04-01-2011 01:29 PM
Pathway towards Cardiac Surgery? saeyed IMG Residency Match Forum 3 12-25-2010 09:54 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)