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Old 04-14-2011
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DNA The prognostic significance of Philadelphia Chromosome

Philadelphia chromosome......... better or worse prognosis...??

In FA step 1 ....... it is written that Philadelphia Chromosome carries better prognosis in ALL patients...... BUT
in FA step 2 ....
.. it writes that presence of Philadelphia chromosome carries a worse prognosis in ALL patients .......??

I can refer to the fact that Philadelphia chromosome is defining CML being characteristic feature ... however not sufficient to be diagnostic since it was discovered to be associated with other leukemias (about 25% of ALL , occasionally in AML)


THEN if the confusing matter of prognosis of it in ALL .. NOT apply on CML

i.e ...it carries favorable prognosis in CML patients....
is that right ....???

???
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Old 04-14-2011
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Arrow Ph+ ALL Patients have better prognosis

The recent use of Imatinib Mesylate in patients with Acute Lymphoblastic Leukemia and Ph+ has dramatically changed the picture.

The BCR/ABL Tyrosin Kinase inhibition by this magical drug has made Ph+ patients actually have a better prognosis than those without it because the drug can even cure the disease.

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Old 04-14-2011
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Thumbs Up thx a lot

Quote:
Originally Posted by Sabio View Post
The recent use of Imatinib Mesylate in patients with Acute Lymphoblastic Leukemia and Ph+ has dramatically changed the picture.

The BCR/ABL Tyrosin Kinase inhibition by this magical drug has made Ph+ patients actually have a better prognosis than those without it because the drug can even cure the disease.

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then this should work exactly also for CML....
THX
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Old 04-14-2011
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Quote:
Originally Posted by cerebrum85 View Post
then this should work exactly also for CML....
THX
Yes, that's correct.
CML prognosis has been tremendously improved after the introduction of Imatinib (brand named Gleevec).

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Old 04-14-2011
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Default cerebrum

Hey thanks .....this was a really interesting Question
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