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Old 05-22-2014
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Default Biochem Question

1. A seven months old infant came with hypoglycemia, jaundice, hemorrhage and hepatomegaly. He was exclusively breast fed for six months except for vitamin D supplementations. On laboratory examination his serum phosphate and potassium levels were found to be low; in addition, he had low arterial pH. Which of the following share similar mechanism in causing electrolyte and acid-base disturbance?
A. Macune-Albright Syndrome
B. Albrightís hereditary Osteodystrophy
C. Ingestion of expired Tetracycline
D. Milk-alkali syndrome
E. Addisonís Disease
Hey guys, I just created this question hope it is not far fetched!
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Old 05-22-2014
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ill go with C.
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Old 05-23-2014
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what is the answer?
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Old 05-23-2014
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Great job. it is C
this infant was exclusively breast fed and when he was weaned developed the above Si. this is classic fructose metabolism defect and from the severity of the disease it is more likely Hereditary Fructose Intolerance, which presents with Fanconi Syndrome like renal manifestations as described. So other causes of Fanconi, among others is ingestion of expired tetracycline.
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