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Old 05-24-2014
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Default Metaplasia

In the pathology textbook ROBBINS , they say that metaplasia occurs because of reprogramming of STEM cells . The examples they have mentioned are of respiratory tract metaplasia-s in cigarrete smokers etc.
BUT THERE ARE NO STEM CELLS IN RESPIRATORY TRACT....I SUPPOSE..
THEN HOW IS IT POSSIBLE ?
ANYONE PLEASE EXPLAIN !
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Old 05-25-2014
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Well, I would've asked you to quote the sentence, but to make this short, I decided to do it myself (it's an advice for next time though).

So It says "Metaplasia is thought to arise by genetic "reprogramming" of stem cells rather than transdifferentiation of already differentiated cells"

It clearly says "It's THOUGHT to ...." And it's true, the latest research is suggesting that in fact that may be what's happening in metaplasia, Robbins as the authority it is in its field, have (I assume) the best and detailed info in the regard.

That said, why are you studying for USMLE with Robbins? it is way to extensive and detailed, that's why there is USMLE-focused material out there you know? but oh well, it never hurts to do some extra reading

I hope this helped with your doubt.
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Old 05-25-2014
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The book states METAPLASIA IS THE RESULT OF A REPROGRAMMING OF STEM CELLS THAT ARE KNOWN TO ExIST IN THE TISSUES.
And I am not able to understand that when there are no stem cells in the respiratory tract , how is metaplasia taking place.
And robbins is my passion...hehe
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Old 05-26-2014
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Quote:
Originally Posted by ANUBHAV View Post
The book states METAPLASIA IS THE RESULT OF A REPROGRAMMING OF STEM CELLS THAT ARE KNOWN TO ExIST IN THE TISSUES.
And I am not able to understand that when there are no stem cells in the respiratory tract , how is metaplasia taking place.
And robbins is my passion...hehe
Dear Anubhav, did you read my previous reply at all?

I invite you to do that and see that I quoted the fragment and also said that LATEST RESEARCH IS SHOWING THAT THERE MAY IN FACT BE STEM CELLS IN RESPIRATORY TISSUES and that new evidence is pointing towards this cells being THE ONE CHANGING IN ALTERATIONS LIKE METAPLASIA.

Google and indexed medical databases are also good friends, dear poster.

Have a good day
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