Calmodulin Function! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 04-27-2011
nicki's Avatar
USMLE Forums Addict
Steps History: 1+CK+CS
Posts: 109
Threads: 27
Thanked 39 Times in 33 Posts
Reputation: 49
Question Calmodulin Function!

hey guys
this may be a totally stupid question
but what is the action of calmodulin?
I always thought calcium bound to it in smooth muscle and then calmodulin activated myosin light chain kinase--->muscle contraction eventually

But UW says calmodulin binds and activates plasma membrane Ca-ATPase, which removes Ca from the cell by hydrolyzing ATP.

I'm so confused now Does it do both?
Reply With Quote Quick reply to this message

Old 04-27-2011
Hope2Pass's Avatar
USMLE Forums Master
Steps History: 1+CK+CS+3
Posts: 1,685
Threads: 213
Thanked 1,583 Times in 660 Posts
Reputation: 1593

I got some information from an online source. Basically, Calcium regulates its concentration through indirect negative feedback. If you click on the source link below you can read up on it in more detail.

Ca2+-ATPase is responsible for extracting calcium from the cytoplasm. An increase in intracellular calcium activates binding to calmodulin which then activates Ca2+-ATPase. This in turn causes calcium to be released from the cytoplasm. This activity establishes a method of maintaining a low level of intracellular calcium through self-regulation. Calcium, therefore, has the ability to regulate its own cellular concentration with the help of calmodulin.

Reply With Quote Quick reply to this message
The above post was thanked by:
nicki (04-27-2011)


Biochemistry-, Physiology-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
function of the nucleosomes khushboo USMLE Step 1 Forum 3 11-21-2011 12:49 AM
Pulmonary Function Test in an Asthmatic RRMadukha USMLE Step 2 CK Forum 5 06-19-2011 01:47 PM
help in lipoprotein function and cycle kemoo USMLE Step 1 Forum 1 01-13-2011 09:44 AM
Function of Carnitine? sam01 USMLE Step 1 Forum 4 04-10-2010 10:52 PM
Qbank Search Function SeattleG3 General Topics Forum 8 12-30-2009 07:39 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)