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Old 04-29-2011
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Thyroid Thyroid question

Hello
I have a question about the thyroid gland and its hormones.
In the Thyroid hormone resistance syndrome, biological tests will show an elevated FT4 and a high TSH, just like in central hyperthyroidism, yet, clinically the patient will either be euthyroid or hypothyroid?
Please correct me if I'm wrong
Thank you
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Old 04-29-2011
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I think u r talking about Low T3 syndrome,

There is dysfunction of the enzyme responsible for the peripheral conversion of T4 to T3.

You will see normal T4 & TSH and low T3.
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Old 04-29-2011
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Quote:
Originally Posted by doc_study View Post
I think u r talking about Low T3 syndrome,

There is dysfunction of the enzyme responsible for the peripheral conversion of T4 to T3.

You will see normal T4 & TSH and low T3.
No sir, not ESS.
I'm talking about global thyroid resistance syndrome, i.e. when there are mutations in the receptors of the thyroid hormones. Seems like TSH and T4 go up to try to compensate. Still, the clinical profile would be that of a hypothyroid person.
Am I wrong?
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Old 06-15-2011
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Yes, wrong

The although the t4 and tsh values youŽll have an unmatched clinical scenario. Sometimes can be euthyroid but with tachycardia and goiter. But, usually patients live asymptomatic the most of the cases.
The alteration is on beta type TRHB receptor.
But colleague, ..this sindrome is THAT rare an uncommon....
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