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Old 04-29-2011
qurat21's Avatar
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Drug Role of beta blocker in tremors?

What's the mechanism by which beta blockers control essential tremors?
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Old 04-29-2011
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Info Peripheral Beta 2 Receptors

There are peripheral adrenergic (specifically Beta 2 receptors) in skeletal muscles.

Stimulation of these B2 receptors leads to repeated contraction (tremor). That's why B2 Agonists (Bronchodilators) have tremor as a major side effect (Please do not confuse it with action on the uterus and bronchioles, stimulation of B2 receptors in those tissues causes relaxation instead of contraction).

Therefore, if you block these receptors (with a beta blocker) you are likely to succeed in treating essential tremors.

However, this is just a theoretical assumption because beta blockers do not work in all patients and therefore there might be other issued involved in the production of essential tremors.

Recently they found not only B2 receptors but also B1 receptors might be involved and therefore a selective B1 antagonist such as Metoprolol might be a good alternative to Propranlol for tremor patients with bronchial asthma for example.
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Old 04-29-2011
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Default Thank you

That was really helpful .. Thank you
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Old 04-30-2011
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thankx fr the reply
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Old 05-03-2011
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No wonder most of my seniors use Propranolol for portal hypertension in patient with Cirrhosis.
(also can treat tremor as a bonus).
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