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Old 04-29-2011
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Kidney Focal segmental Glomerulosclerosis

hello, some confusion here

In Goljan RR, it says negative IF for FSGS.

but in Pretest Pathology, for FSGS it says :

Electron microscopy shows increased mesangial matrix
and dense granular mesangial deposits. Immunofluorescence typically shows
granular mesangial fluorescence for IgM and C3. Although FSGS can be associated with several disorders such as HIV
infection, heroin use, and sickle cell disease, it can also be primary (idiopathic)
disorder. Some of these primary cases in fact have a genetic basis
and are related to mutations of genes coding for protein products of the slit
diaphragm of the glomerulus. One of these is the protein podocin, which
is coded for by the NPHS2 gene.

My conclusion: The IgM/C3 IF are just trapped in the sclerosing process?
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noothan (04-29-2011)



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Old 04-29-2011
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check this out:

http://books.google.com/books?id=BUE...erosis&f=false
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Daniel Wai (04-29-2011)



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