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Old 04-30-2011
INCOGNITO's Avatar
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Question Alcoholic patient question

A 55 YEAR-OLD ALCOHOLIC PATIENT WAS BROUGHT TO E/R BY HIS FRIENDS.DURING THEIR ROUTINE NIGHT GATHERING AT ALCOHOL BAR,HE HAD BEEN PASSED OUT AND THEY HAD BEEN UNABLE TO REVIVE HIM.
PHYSICIAN ORDERED AND INJECTION OF THIAMINE FOLLOWED BY I/V GLUCOSE.
THE NEXT MORNING PT WAS ALERT AND COHERENT,SERUM THIAMINE WAS NORMAL AND BLOOD GLUCOSE WAS 73mg/dL(4mM)).
THE I/V LINE WAS REMOVED AND HE WAS TAKEN HOME...

1)WHICH ONE OF FOLLOWING ENZYME IS THIAMINE DEPENDENT AND ESSENTIAL FOR GLUCOSE OXIDATION IN BRAIN..

A)TRANSKETOLASE
B)PYRUVATE DEHYDROGENASE
C)SUCCINYL CO-A
D)ACETYL CO-A
E)SUCCINYL CO-A

2)AT TIME OF DISCHARGE FROM HOSPITAL WHICH OF FOLLOWING PROTEINS WOULD HAVE NO SIGNIFICANT ACTIVITY IN THIS PT.

A)MALATE DEHYDROGENASE
B)GLUT-1 TRANSPORTER
C)ALPHA KETOGLUTARATE DEHYDROGENASE
D)PHOSPHOFRUCTOKINASE
E)GLUCOKINASE
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  #2  
Old 05-01-2011
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1 - B
TLCFN enzyme PDH. THE FIRST TRANSKETOLASE IS IN HMP SHUNT AND IT'S TPP DEPENDENT BUT NOT ESSENTIAL FOR GLYCOLYSIS. C-D-E ARE NOT ENZYMES THEY ARE JUST PRODUCTS

2 - E GLUCOKINASE WILL NOT HAVE SIGNIFICANT PHYSIOLOGIC ACTIVITY. IT'S LOCATES IN LIVER AN Km IS ANOUT 15. SO AT THIS TIME GLUKOSE LEVEL WILL NOT BE SO HIGH. OTHER ENYMES ARE NEEDED TO PROVIDE NORMAL GLYCOLYSIS.


THESE Q WAS IN kln BIOCHEMISTRY AS I REMEMBER
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  #3  
Old 05-01-2011
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Exactly,
1. B
2. E

=)
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