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Old 06-11-2014
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Default Beta 1 agonists and diastolic blood pressure

Why do Beta 1 agonists cause decrease in diastolic blood pressure? I know it increases the systolic blood pressure, but I don't understand how it decreases the diastolic blood pressure. Can anyone please explain the mechanism involved!
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Old 06-11-2014
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Finally found the answer! The question should have been, why do beta agonists cause decrease in diastolic blood pressure!


"Epinephrine stimulates beta1 receptors to cause an increase in systolic blood pressure, heart rate, and cardiac output. There is a modest decrease in diastolic blood pressure, reflecting vasodilation in skeletal muscle vasculature due to stimulation of beta2 receptors. The net effect of these peripheral vascular changes is preferential distribution of cardiac output to skeletal muscles and decreased systemic vascular resistance."

Source: Pharmacology & Physiology in Anesthetic Practice
by Robert K. Stoelting and Simon C. Hillier

Last edited by eizou; 06-11-2014 at 07:40 PM.
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