Cytotoxic Versus Non-Cytotoxic Type II Hypersensitivity Reaction - USMLE Forums
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Old 05-04-2011
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Immunology Cytotoxic Versus Non-Cytotoxic Type II Hypersensitivity Reaction

HI guys,
During my review over Qbank Kaplan i found a lot of information regarding Type 2 Hypersensitivy dirsorders for example...

Grave, MG, Pernicious Anemia are NON cytotoxic Type 2 and Erythroblastosis fetalis, RA are Cytotoxic Hyper type 2...

I memorized those one, but how do i approach to select know which is one without memorize it... Any clue ? Thanks in advanced....
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Old 05-04-2011
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If you know what the diseases are, then you should be able to figure out which is cytotoxic vs non-cytotoxic. Type II hypersensitivity means you have antibodies against a fixed cell component. Cytotoxic means that these antibodies kill the cell, noncytotoxic means it doesn't kill the cell but it interferes with it's function.
Example:
1. Erythroblastosis fetalis: the antibodies bind to the red blood cells and cause them to lyse, i.e. it kills the cell so it's cytotoxic.
2. Myasthenia gravis: antibodies bind to the ACh receptors on the cell and prevent ACh from binding and activating it, so it interferes with it's function. The cell is still alive, so it's noncytotoxic.
Grave's: Antibody bind to the TSH receptor and keeps it over-activated; clearly the cell isn't dead since it's secreting stuff, therefore this is noncytotoxic.
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Old 05-04-2011
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Quote:
Originally Posted by heights View Post
If you know what the diseases are, then you should be able to figure out which is cytotoxic vs non-cytotoxic. Type II hypersensitivity means you have antibodies against a fixed cell component. Cytotoxic means that these antibodies kill the cell, noncytotoxic means it doesn't kill the cell but it interferes with it's function.
Example:
1. Erythroblastosis fetalis: the antibodies bind to the red blood cells and cause them to lyse, i.e. it kills the cell so it's cytotoxic.
2. Myasthenia gravis: antibodies bind to the ACh receptors on the cell and prevent ACh from binding and activating it, so it interferes with it's function. The cell is still alive, so it's noncytotoxic.
Grave's: Antibody bind to the TSH receptor and keeps it over-activated; clearly the cell isn't dead since it's secreting stuff, therefore this is noncytotoxic.

Nice approach, now i understand... Thanks.
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Old 05-04-2011
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This can help also
Non Cytotoxic Type II hypersensitivity Diseases
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Old 05-04-2011
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perfect! thank you!
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