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Old 07-24-2009
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Liver PT PTT in Liver Disease?

Hey what's up with PT PTT in liver disease
I've seen a question in Kaplan Q book saying that only PT is elevated!
Isn't it both as all clotting factors decreased?
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Old 07-24-2009
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if they gave two choices pt alone and pt and ptt then you must choose that both pt and ptt prolonged
But I looked up the issue
theoretically speaking factor VII has a short half life so it tends to disappear from the circulation before the other factors
remember that factor VII is only present in the extrinsic pathway so assessed by PT not PTT
therefore, perhaps early on in liver disease you get only PT increased then all the factors will disappear giving both PT and PTT prolongation
All factors are produced in the liver except factor VIII
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Old 07-31-2016
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so where is F8 produced?
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Old 08-01-2016
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Quote:
Originally Posted by gofish6060 View Post
so where is F8 produced?
vascular endothelial cell
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