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Old 06-14-2014
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Default How insulin increase here?

I have recentely see USMLE Pass Programme video

In it they told
Insulin go everywhere except BRICKLE.
B:brain
R:RBC
I:intestine
C:cardiac
K:kidney
L:liver
E:exercing muscle

I am confused about last one because insulin require for glucose transport during exercise...so can any one explain it easily plz?
Thanks
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Old 06-14-2014
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Resting skeletal muscles are always insulin-dependent, meaning that they require insulin for glucose uptake which is done through insulin upregulating GLUT4 receptors and causing them to translocate to the cell surface.
Exercising skeletal muscles have insulin-independent means of upregualting their GLUT4 receptors, one of which was mentioned in kaplan biochem book and was called 5-AMP-dependent kinase if I remember correctly.
This is very rational since exercising muscle require a lot of glucose and therefore should not only depend on insulin for glucose uptake.
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Quote:
Originally Posted by federer_1490 View Post
Resting skeletal muscles are always insulin-dependent, meaning that they require insulin for glucose uptake which is done through insulin upregulating GLUT4 receptors and causing them to translocate to the cell surface.
Exercising skeletal muscles have insulin-independent means of upregualting their GLUT4 receptors, one of which was mentioned in kaplan biochem book and was called 5-AMP-dependent kinase if I remember correctly.
This is very rational since exercising muscle require a lot of glucose and therefore should not only depend on insulin for glucose uptake.
Here i also confuced about liver also bcz many enzyme of liver regulated by insulin
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Old 06-14-2014
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Yeah insulin controls many processes in the liver. However, glucose uptake isn't one of them.
The thing u have to understand is that adipose tissue and skeletal muscles are almost impermeable to glucose in the absence of insulin. The reason behind that is that their glucose transporters GLUT4 are not present on the cell surface but rather in the cytoplasm within vesicles and they require insulin to be transported to cell surface and assume their function.
Other tissues have glucose transporters that are always present on the cell surface which make the tissues possessing them insulin-independent.
The liver for example has GLUT2 which is always on the cell surface and this makes the liver an insulin-independent organ.
My understanding of this concept is that most tissues are insulin-independent except for adipose tissue and resting skeletal muscles.
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