Immunological Mechanism of Hemolytic Transfusion Reaction! - USMLE Forums
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  #1  
Old 05-10-2011
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Blood Immunological Mechanism of Hemolytic Transfusion Reaction!

A patient with blood group O undergoing an operation for repair of an aortic aneurysm is mistakenly transfused with group A unit of packed RBCs. He immediately goes into shock. A blood sample is markedly hemolyzed. Which of the following is the primary mechanism for the hemolysis?

a. Action by properdin to cleave C3
b. Action of C5-9 complex of complement
c. Activation of factor XII (Hageman factor)
d. Production of C5a to stimulate phagocytosis
e. Release of histamine by the action of C5a
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Old 05-10-2011
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b. Action of C5-9 complex of complement

The hemolysis would be antibody mediated which take the Classic pathway.
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Old 05-10-2011
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I agree... But the answer key says it's A. I have NO idea what that is! Do you?
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Old 05-10-2011
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hmmm...

I dont know...what source you are using.

More about option A.
http://en.wikipedia.org/wiki/Properdin
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It was just the answer key that came with NMBE 5... I never rely on those but I was just wondering. I took NMBE 5 online and put B. Thanks for the info!
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Warning! NBME question

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Originally Posted by Dr_Laura View Post
It was just the answer key that came with NMBE 5... I never rely on those but I was just wondering. I took NMBE 5 online and put B. Thanks for the info!
Thanks for this valuable information, but I would suggest that in the future if you want to put NBME questions please write it on the top "NBME QUESTION". It doesn't do any good to those who still have to take the online test and if we know the question and the answer already, we might get a wrong predicted score. Hope I didn't offend you with this. Thanks
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Sorry... Thanks to all that answered
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I thought the ADMINS banned posting NBME questions?
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Sorry, I always see people asking NBME questions so I thought it was ok. I was just reported and they sent me a notification so thank you and I'm sorry. I did not know that this was not allowed.
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