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Old 05-11-2011
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Question Understanding Oncotic/Hydrostatic Pressure

Hey Guys,

I understand what oncotic and hydrostatic pressure is in terms of definitions, but I would like to know the pathologies of edema in relation to affecting these.

I.e. I know nephrotic syndrome decreases capillary oncotic pressure leading to edema. but what are the other pathologies associated with edema and how they effect oncotic/hydrostatic pressure...i.e what does a lymphatic obstruction etc...

Thank you!
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Old 05-11-2011
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Let's see...
knowing the starling equation:

you can easily come up with pathologies which lead to edema in other words - increased filtration coefficient for e.g. infections, burns, toxins which increase capillary permeability etc.
Plasma hydrostatic pressure increases in CHF, cirrhosis of the liver, bud chiari syndrome, portal vein thrombosis in pregnancy or any hypercoaguble state etc schistosomiasis mansoni infection, cor pulmonale secondary to obstructive sleep apnea etc.

Plasma oncotic pressure decreases in protein losing enteropathies, decreased protein intake in malnutrition, liver cirrhosis and nephrotic syndrome etc.

Lymphatic obstruction occurs in elephantiasis etc,

Hope this helps!
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Old 05-11-2011
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thank you! so in the case of lymphatic obstruction, would it be increased interstitial oncotic pressure...drawing fluid out?
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Old 05-11-2011
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Quote:
Originally Posted by kmudambi1 View Post
thank you! so in the case of lymphatic obstruction, would it be increased interstitial oncotic pressure...drawing fluid out?

In case of lymphatic obstruction, the plasma proteins that cross the cell membrane of the capillary are in the interstitial compartment, they are normally removed via lymphatics. If the lymphatics are blocked, protein will accumulate, and will result in increased drawing of fluid leading to edema.

So yes, increased Ic.
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